• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

地中海被囊动物的新型生物活性烷基硫酸盐。

New bioactive alkyl sulfates from Mediterranean tunicates.

机构信息

The NeaNat Group, Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli "Federico II", Via D. Montesano 49, 80131 Napoli, Italy.

出版信息

Molecules. 2012 Oct 26;17(11):12642-50. doi: 10.3390/molecules171112642.

DOI:10.3390/molecules171112642
PMID:23103530
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6268736/
Abstract

Chemical investigation of two species of marine ascidians, Aplidium elegans and Ciona edwardsii, collected in Mediterranean area, led to isolation of a series of alkyl sulfates (compounds 1-5) including three new molecules 1-3. Structures of the new metabolites have been elucidated by spectroscopic analysis. Based on previously reported cytotoxic activity of these type of molecules, compounds 1-3 have been tested for their effects on the growth of two cell lines, J774A.1 (BALB/c murine macrophages) and C6 (rat glioma) in vitro. Compounds 1 and 2 induced selective concentration-dependent mortality on J774A.1 cells.

摘要

从地中海采集的两种海洋海鞘，Aplidium elegans 和 Ciona edwardsii 中进行的化学研究导致分离出一系列烷基硫酸盐（化合物 1-5），其中包括三种新分子 1-3。通过光谱分析阐明了新代谢产物的结构。基于这些类型分子先前报道的细胞毒性活性，测试了化合物 1-3 对两种细胞系 J774A.1（BALB/c 鼠巨噬细胞）和 C6（大鼠神经胶质瘤）体外生长的影响。化合物 1 和 2 诱导 J774A.1 细胞选择性浓度依赖性死亡。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7d6/6268736/74332f815f9f/molecules-17-12642-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7d6/6268736/d6003dcd66ba/molecules-17-12642-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7d6/6268736/74332f815f9f/molecules-17-12642-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7d6/6268736/d6003dcd66ba/molecules-17-12642-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7d6/6268736/74332f815f9f/molecules-17-12642-g002.jpg

相似文献

1
New bioactive alkyl sulfates from Mediterranean tunicates.地中海被囊动物的新型生物活性烷基硫酸盐。
Molecules. 2012 Oct 26;17(11):12642-50. doi: 10.3390/molecules171112642.
2
Zorrimidazolone, a bioactive alkaloid from the non-indigenous mediterranean stolidobranch Polyandrocarpa zorritensis.佐利米达唑酮，一种来自非本地地中海厚壳贻贝 Polyandrocarpa zorritensis 的生物活性生物碱。
Mar Drugs. 2011;9(6):1157-1165. doi: 10.3390/md9061157. Epub 2011 Jun 23.
3
Aplidiasterols A and B, two new cytotoxic 9,11-secosterols from the Mediterranean ascidian Aplidium conicum.锥海鞘素A和B，两种来自地中海海鞘锥海鞘的新型细胞毒性9,11-断甾体。
Steroids. 2003 Oct;68(9):719-23. doi: 10.1016/s0039-128x(03)00098-9.
4
Sulfated compounds from marine organisms.来自海洋生物的硫酸化化合物。
Comp Biochem Physiol B Biochem Mol Biol. 1998 Jan;119(1):1-51. doi: 10.1016/s0305-0491(97)00168-5.
5
Phallusiasterols A and B: two new sulfated sterols from the Mediterranean tunicate Phallusia fumigata and their effects as modulators of the PXR receptor.海鞘甾醇A和B：来自地中海海鞘烟海鞘的两种新型硫酸化甾醇及其作为孕烷X受体调节剂的作用。
Mar Drugs. 2014 Apr 3;12(4):2066-78. doi: 10.3390/md12042066.
6
New bioactive sulfated alkenes from the sea cucumber Apostichopus japonicus.从海参中提取的新型生物活性磺酸烯。
Chem Biodivers. 2012 Jun;9(6):1166-71. doi: 10.1002/cbdv.201100324.
7
Iodocionin, a cytotoxic iodinated metabolite from the Mediterranean ascidian Ciona edwardsii.碘代辛可宁，一种来自地中海贻贝 Ciona edwardsii 的细胞毒性碘代代谢产物。
Mar Drugs. 2010 Feb 21;8(2):285-91. doi: 10.3390/md8020285.
8
A novel sperm-activating and attracting factor from the ascidian Ascidia sydneiensis.一种来自海鞘 Ascidia sydneiensis 的新型精子激活和吸引因子。
Org Lett. 2013 Jan 18;15(2):294-7. doi: 10.1021/ol303172n. Epub 2013 Jan 4.
9
New sesterterpene sulfates from the sponge Darwinella australensis.来自澳大利亚达尔文海绵的新型半萜硫酸盐。
J Nat Prod. 2003 Jul;66(7):1010-2. doi: 10.1021/np030141p.
10
Bioactive sulfated sesterterpene alkaloids and sesterterpene sulfates from the marine sponge Fasciospongia sp.海洋海绵 Fasciospongia sp. 中的生物活性硫酸化甾体生物碱和甾体硫酸盐
J Nat Prod. 2009 Feb 27;72(2):319-23. doi: 10.1021/np8005343.

引用本文的文献

1
The Mediterranean Sea on the Bench: Unveiling the Marine Invertebrate as a Source of Novel Promising Therapeutic Tools Against Triple-Negative Breast Cancer.实验台上的地中海：揭示海洋无脊椎动物作为对抗三阴性乳腺癌的新型有前景治疗工具的来源。
Mar Drugs. 2025 Apr 29;23(5):195. doi: 10.3390/md23050195.
2
Bioactive Aliphatic Sulfates from Marine Invertebrates.海洋无脊椎动物中的生物活性脂肪族硫酸盐。
Mar Drugs. 2019 Sep 9;17(9):527. doi: 10.3390/md17090527.
3
Natural Products Diversity of Marine Ascidians (Tunicates; Ascidiacea) and Successful Drugs in Clinical Development.

本文引用的文献

1
Aplisulfamines, new sulfoxide-containing metabolites from an aplidium tunicate: absolute stereochemistry at chiral sulfur and carbon atoms assigned through an original combination of spectroscopic and computational methods.来自 aplidium 被囊动物的新含亚砜代谢物 aplisulfamines：通过光谱和计算方法的原始组合确定手性硫和碳原子的绝对立体化学。
Mar Drugs. 2012 Jan;10(1):51-63. doi: 10.3390/md10010051. Epub 2012 Jan 4.
2
Zorrimidazolone, a bioactive alkaloid from the non-indigenous mediterranean stolidobranch Polyandrocarpa zorritensis.佐利米达唑酮，一种来自非本地地中海厚壳贻贝 Polyandrocarpa zorritensis 的生物活性生物碱。
Mar Drugs. 2011;9(6):1157-1165. doi: 10.3390/md9061157. Epub 2011 Jun 23.
3
海洋被囊动物（被囊类；海鞘纲）的天然产物多样性及临床开发中的成功药物
Nat Prod Bioprospect. 2017 Feb;7(1):1-111. doi: 10.1007/s13659-016-0115-5. Epub 2017 Jan 17.
Effects of non-dioxin-like polychlorinated biphenyl congeners (PCB 101, PCB 153 and PCB 180) alone or mixed on J774A.1 macrophage cell line: modification of apoptotic pathway.
单独或混合使用非二恶英类多氯联苯同系物（PCB 101、PCB 153 和 PCB 180）对 J774A.1 巨噬细胞系的影响：凋亡途径的改变。
Toxicol Lett. 2011 Apr 10;202(1):61-8. doi: 10.1016/j.toxlet.2011.01.023. Epub 2011 Feb 1.
4
Iodocionin, a cytotoxic iodinated metabolite from the Mediterranean ascidian Ciona edwardsii.碘代辛可宁，一种来自地中海贻贝 Ciona edwardsii 的细胞毒性碘代代谢产物。
Mar Drugs. 2010 Feb 21;8(2):285-91. doi: 10.3390/md8020285.
5
Sodium 1-(12-hydroxy)octadecanyl sulfate, an MMP2 inhibitor, isolated from a tunicate of the family Polyclinidae.
J Nat Prod. 2002 Dec;65(12):1936-8. doi: 10.1021/np020250o.
6
Thrombin and PAR-1 activating peptide increase iNOS expression in cytokine-stimulated C6 glioma cells.凝血酶和PAR-1激活肽可增加细胞因子刺激的C6胶质瘤细胞中诱导型一氧化氮合酶的表达。
J Neurochem. 2001 Nov;79(3):556-63. doi: 10.1046/j.1471-4159.2001.00617.x.
7
New bioactive sulfated metabolites from the Mediterranean tunicate Sidnyum turbinatum.来自地中海被囊动物陀螺锡德海鞘的新型生物活性硫酸化代谢产物。
J Nat Prod. 2001 Feb;64(2):219-21. doi: 10.1021/np000438c.
8
Novel bioactive sulfated alkene and alkanes from the mediterranean ascidian Halocynthia papillosa.来自地中海海鞘乳头海鞘的新型生物活性硫酸化烯烃和烷烃。
J Nat Prod. 2000 Nov;63(11):1590-2. doi: 10.1021/np000281o.
9
Steroids from sponges: recent reports.来自海绵的类固醇：近期报告。
Steroids. 1999 Oct;64(10):687-714. doi: 10.1016/s0039-128x(99)00032-x.
10
Antibacterial and antifungal sulfated alkane and alkenes from the hepatopancreas of the ascidian Halocynthia roretzi.来自海鞘柄海鞘肝胰腺的具有抗菌和抗真菌活性的硫酸化烷烃和烯烃。
J Nat Prod. 1994 Nov;57(11):1606-9. doi: 10.1021/np50113a027.