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碘代辛可宁，一种来自地中海贻贝 Ciona edwardsii 的细胞毒性碘代代谢产物。

Iodocionin, a cytotoxic iodinated metabolite from the Mediterranean ascidian Ciona edwardsii.

机构信息

Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli Federico II, Napoli, Italy.

出版信息

Mar Drugs. 2010 Feb 21;8(2):285-91. doi: 10.3390/md8020285.

DOI:10.3390/md8020285
PMID:20390106
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2852839/
Abstract

Chemical investigation of the Mediterranean ascidian Ciona edwardsii has been performed, leading to the isolation of two halogenated compounds: a new tyrosineiodinated derivative iodocionin (1) and the relevant brominated analogue (2), previously isolated from a Caribbean sponge. The structure of the new compound 1 has been assigned on the basis of spectroscopic analysis. Both compounds were tested for cytotoxicity in vitro against two different cancer cell lines, L5178Y (mouse lymphoma) and PC-12 (rat pheochromocytoma). Iodocionin was shown to possess significant and selective activity against lymphoma cells with an IC(50) of 7.75 microg/mL.

摘要

对地中海海鞘 Ciona edwardsii 进行了化学研究，分离得到两种卤代化合物：一种新型酪氨酸碘化衍生物碘代海鞘素（1）和以前从加勒比海绵中分离得到的相关溴代类似物（2）。根据光谱分析确定了新化合物 1 的结构。两种化合物均在体外针对两种不同的癌细胞系（L5178Y（小鼠淋巴瘤）和 PC-12（大鼠嗜铬细胞瘤））进行了细胞毒性测试。结果表明，碘代海鞘素对淋巴瘤细胞具有显著的选择性活性，IC50 为 7.75μg/mL。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09e6/2852839/c508c98acfaa/marinedrugs-08-00285f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09e6/2852839/24c4fa45a2d8/marinedrugs-08-00285f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09e6/2852839/c508c98acfaa/marinedrugs-08-00285f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09e6/2852839/24c4fa45a2d8/marinedrugs-08-00285f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09e6/2852839/c508c98acfaa/marinedrugs-08-00285f2.jpg

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