余甘子果实对消炎痛诱导的大鼠胃溃疡愈合的抗氧化作用。
Antioxidant effect ofPhyllanthus emblica fruits on healing of indomethacin induced gastric ulcer in rats.
作者信息
Pakrashi Anita, Pandit Srikanta, Bandyopadhyay Sandip K, Pakrashi Satyesh C
机构信息
Department of Biochemistry, Indian Institute of Chemical Biology, 244B, Acharya J. C. Bose Road, 700 032 Kolkata.
出版信息
Indian J Clin Biochem. 2003 Jan;18(1):15-21. doi: 10.1007/BF02867660.
Abstract
Post-treatment of the indomethacin induced ulcerated rats at the optimal dose of 100 mg/kg body-wt. orally for 7 consecutive days with the lyophilized aqueous extract of the fruits ofPhyllanthus emblica L. syn.Emblica officinalis Gaertn. (Euphorbiaceae) exhibited highly significant (p<0.001) enhancement of secretion of catalase, reduced glutathione and decrease in malonyldialdehyde (MDA). Furthermore, the gross morphological observation and highly significant (p<0.001) decrease of ulcer index (81.43%) indicated healing effect of the extract on gastric ulcer.
摘要
以100毫克/千克体重的最佳剂量对消炎痛诱导的溃疡大鼠进行口服处理，连续7天给予余甘子（大戟科）果实的冻干水提取物，结果显示过氧化氢酶、还原型谷胱甘肽的分泌显著增强（p<0.001），丙二醛（MDA）含量降低。此外，大体形态学观察以及溃疡指数显著降低（81.43%，p<0.001）表明该提取物对胃溃疡具有愈合作用。
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