尼可地尔和氨氯地平对异丙肾上腺素诱导的大鼠心肌坏死过程中生化参数的影响。
Effect of nicorandil and amlodipine on bio-chemical parameters during isoproterenol induced myocardial necrosis in rats.
作者信息
Singh Narinder, Kumar Rahat
机构信息
Deptt. Of Pharmacology, S. G. R. D. Inst. of Med. Sc. & Research, Amritsar.
出版信息
Indian J Clin Biochem. 2003 Jan;18(1):99-102. doi: 10.1007/BF02867674.
OBJECTIVE
To investigate the protective effect of nicorandil and amlodipine in isoproterenol induced myocardial necrosis in rats.
METHODS
The effect of nicorandil and amlodipine on bio-chemical parameters during isoproterenol induced myocardial necrosis in rats was examined by determining the activity of creatine phosphokinase (CK), lactate dehydrogenase (LDH), and transaminases (AST, ALT) in the serum of the animals.
RESULTS
Isoproterenol (150mg/kg/day) administered rats showed statistically significant rise in activities of LDH(1.02±0.19 to 1.85±0.05), CK(4.3±0.19 to 7.37±.27), AST(0.38±.03 to 0.78±.05) and ALT(0.19±.017 to 0.346±.027) in the serum. Pre-co-treatment of rats with nicorandil and amlodipine significantly lowered the raised levels of these enzymes and thereby restoring the enzyme activity to near normal as was clear from the chart i.e. LDH was 1.10±0.04, CK was 4.37±0.19, AST and ALT were 0.39±0.028 and 0.199±0.04 respectively.
CONCLUSION
It is demonstrated that pre-co-treatment with nicorandil and amlodipine either alone or in combination help in providing protective effect on isoproterenol induced myocardial necrosis.
目的
研究尼可地尔和氨氯地平对异丙肾上腺素诱导的大鼠心肌坏死的保护作用。
方法
通过测定动物血清中肌酸磷酸激酶（CK）、乳酸脱氢酶（LDH）和转氨酶（AST、ALT）的活性，检测尼可地尔和氨氯地平对异丙肾上腺素诱导的大鼠心肌坏死过程中生化参数的影响。
结果
给予异丙肾上腺素（150mg/kg/天）的大鼠血清中LDH（从1.02±0.19升至1.85±0.05）、CK（从4.3±0.19升至7.37±0.27）、AST（从0.38±0.03升至0.78±0.05）和ALT（从0.19±0.017升至0.346±0.027）的活性有统计学意义的升高。用尼可地尔和氨氯地平预先处理大鼠可显著降低这些酶升高的水平，从而使酶活性恢复到接近正常，从图表中可明显看出，即LDH为1.10±0.04，CK为4.37±0.19，AST和ALT分别为0.39±0.028和0.199±0.04。
结论
结果表明，单独或联合使用尼可地尔和氨氯地平进行预处理有助于对异丙肾上腺素诱导的心肌坏死提供保护作用。
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