诃子干果水提取物对实验性糖尿病的降血糖作用
Antihyperglycemic effect of water extract of dry fruits ofTerminalia chebula in experimental diabetes mellitus.
作者信息
Murali Y K, Chandra Ramesh, Murthy P S
机构信息
Dr B.R. Ambedkar Center for Biomedical Research, University of Delhi, 110007 Delhi.
出版信息
Indian J Clin Biochem. 2004 Jul;19(2):202-4. doi: 10.1007/BF02894285.
Abstract
Water extract of dry fruits ofTerminalia chebula (Hindi-Harda, Telugu-Karakkaya) at a dose of 200 mg/kg body weight improved the glucose tolerance as indicated by 44% of reduction in the peak blood glucose at 2(nd) hour in glucose tolerance test in diabetic (streptozotocin induced) rats. Treatment of diabetic rats with an initial fasting blood glucose of 253±9.4 mg/dl daily once with the water extract (200 mg/kg) for two weeks brought down the fasting blood glucose to 123±8.4 mg/dl which is only slightly above the normal value. These results indicate that water extract of Terminalia chebula improves glucose tolerance and brings down fasting blood glucose in diabetic rats.
摘要
诃子（印地语 - 哈达，泰卢固语 - 卡拉卡亚）干果的水提取物，以200毫克/千克体重的剂量给药，改善了葡萄糖耐量，这在糖尿病（链脲佐菌素诱导）大鼠的葡萄糖耐量试验中表现为第2小时时血糖峰值降低了44%。对初始空腹血糖为253±9.4毫克/分升的糖尿病大鼠，每天一次用水提取物（200毫克/千克）治疗两周后，空腹血糖降至123±8.4毫克/分升，仅略高于正常值。这些结果表明，诃子水提取物可改善糖尿病大鼠的葡萄糖耐量并降低空腹血糖。
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