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无义抑制基因可部分恢复酵母中无义突变等位基因mRNA水平的降低。

Nonsense suppressors partially revert the decrease of the mRNA level of a nonsense mutant allele in yeast.

作者信息

Gozalbo D, Hohmann S

机构信息

Institut für Mikrobiologie, Technische Hochschule Darmstadt, Federal Republic of Germany.

出版信息

Curr Genet. 1990 Jan;17(1):77-9. doi: 10.1007/BF00313252.

DOI:10.1007/BF00313252
PMID:2311129
Abstract

suc2 degrees is a naturally occurring amber mutant allele of the yeast invertase structural gene SUC2. Strains carrying suc2 degrees had only 10% of the wild type invertase-specific mRNA level. Amber suppressors, which allowed suc2 degree strains to ferment sucrose caused an increase of the SUC-specific mRNA level.

摘要

suc2°是酵母转化酶结构基因SUC2的一个天然存在的琥珀突变等位基因。携带suc2°的菌株的野生型转化酶特异性mRNA水平仅为10%。琥珀抑制子使suc2°菌株能够发酵蔗糖，导致SUC特异性mRNA水平升高。

相似文献

1
Nonsense suppressors partially revert the decrease of the mRNA level of a nonsense mutant allele in yeast.无义抑制基因可部分恢复酵母中无义突变等位基因mRNA水平的降低。
Curr Genet. 1990 Jan;17(1):77-9. doi: 10.1007/BF00313252.
2
The naturally occurring silent invertase structural gene suc2 zero contains an amber stop codon that is occasionally read through.天然存在的沉默转化酶结构基因suc2零包含一个琥珀色终止密码子，该密码子偶尔会被通读。
Mol Gen Genet. 1989 Apr;216(2-3):511-6. doi: 10.1007/BF00334398.
3
SSN20 is an essential gene with mutant alleles that suppress defects in SUC2 transcription in Saccharomyces cerevisiae.SSN20是一个必需基因，其突变等位基因可抑制酿酒酵母中SUC2转录的缺陷。
Mol Cell Biol. 1987 Feb;7(2):672-8. doi: 10.1128/mcb.7.2.672-678.1987.
4
Clues to the origin of high external invertase activity in immobilized growing yeast: prolonged SUC2 transcription and less susceptibility of the enzyme to endogenous proteolysis.固定化生长酵母中高外切转化酶活性起源的线索：SUC2转录延长及该酶对内源蛋白水解的敏感性降低
Can J Microbiol. 1999 May;45(5):413-7. doi: 10.1139/w99-024.
5
New SNF genes, GAL11 and GRR1 affect SUC2 expression in Saccharomyces cerevisiae.新的SNF基因GAL11和GRR1影响酿酒酵母中SUC2的表达。
Genetics. 1991 Nov;129(3):675-84. doi: 10.1093/genetics/129.3.675.
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Invertase gene (SUC2) of Saccharomyces cerevisiae as a dominant marker for transformation of Pichia pastoris.酿酒酵母的蔗糖酶基因（SUC2）作为巴斯德毕赤酵母转化的显性标记。
Gene. 1987;59(1):115-25. doi: 10.1016/0378-1119(87)90272-1.
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A suppressor of SNF1 mutations causes constitutive high-level invertase synthesis in yeast.SNF1突变的一个抑制因子可导致酵母中组成型高水平蔗糖酶合成。
Genetics. 1984 May;107(1):19-32. doi: 10.1093/genetics/107.1.19.
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Differential expression of the invertase-encoding SUC genes in Saccharomyces cerevisiae.酿酒酵母中蔗糖酶编码SUC基因的差异表达。
Gene. 1992 Oct 12;120(1):59-65. doi: 10.1016/0378-1119(92)90009-e.
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Suppressors of SNF2 mutations restore invertase derepression and cause temperature-sensitive lethality in yeast.SNF2突变的抑制子可恢复蔗糖酶去阻遏作用，并在酵母中导致温度敏感型致死性。
Genetics. 1986 Apr;112(4):741-53. doi: 10.1093/genetics/112.4.741.
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Organization of the SUC gene family in Saccharomyces.酿酒酵母中SUC基因家族的组织方式。
Mol Cell Biol. 1983 Mar;3(3):351-9. doi: 10.1128/mcb.3.3.351-359.1983.

引用本文的文献

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Nonsense-Mediated mRNA Decay: Degradation of Defective Transcripts Is Only Part of the Story.无义介导的mRNA衰变：缺陷转录本的降解只是其中一部分。
Annu Rev Genet. 2015;49:339-66. doi: 10.1146/annurev-genet-112414-054639. Epub 2015 Oct 2.
2
NMD: At the crossroads between translation termination and ribosome recycling.无义介导的mRNA降解（NMD）：处于翻译终止与核糖体循环的交叉点
Biochimie. 2015 Jul;114:2-9. doi: 10.1016/j.biochi.2014.10.027. Epub 2014 Nov 13.
3
The intimate relationships of mRNA decay and translation.mRNA 衰变与翻译的密切关系。

本文引用的文献

1
Effect of ochre nonsense mutations on yeast URA1 mRNA stability.矿硃无义突变对酵母 URA1 mRNA 稳定性的影响。
Curr Genet. 1984 May;8(4):277-82. doi: 10.1007/BF00419725.
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The influence of codon context on genetic code translation.密码子上下文对遗传密码翻译的影响。
Nature. 1980 Jul 10;286(5769):123-7. doi: 10.1038/286123a0.
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Genetic evidence for a silent SUC gene in yeast.酵母中沉默SUC基因的遗传证据。
Trends Genet. 2013 Dec;29(12):691-9. doi: 10.1016/j.tig.2013.09.002. Epub 2013 Sep 30.
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Yeast Upf1 CH domain interacts with Rps26 of the 40S ribosomal subunit.酵母 Upf1 CH 结构域与 40S 核糖体亚基的 Rps26 相互作用。
RNA. 2013 Aug;19(8):1105-15. doi: 10.1261/rna.039396.113. Epub 2013 Jun 25.
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NMD: a multifaceted response to premature translational termination.NMD：一种针对过早翻译终止的多方面反应。
Nat Rev Mol Cell Biol. 2012 Nov;13(11):700-12. doi: 10.1038/nrm3454. Epub 2012 Oct 17.
6
Testing the faux-UTR model for NMD: analysis of Upf1p and Pab1p competition for binding to eRF3/Sup35p.检测 NMD 的假 UTR 模型：Upf1p 和 Pab1p 竞争结合 eRF3/Sup35p 的分析。
Biochimie. 2012 Jul;94(7):1560-71. doi: 10.1016/j.biochi.2011.12.021. Epub 2012 Jan 2.
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Leaky termination at premature stop codons antagonizes nonsense-mediated mRNA decay in S. cerevisiae.酿酒酵母中过早终止密码子处的渗漏终止拮抗无义介导的mRNA降解。
RNA. 2004 Apr;10(4):691-703. doi: 10.1261/rna.5147804.
8
Nonsense-containing mRNAs that accumulate in the absence of a functional nonsense-mediated mRNA decay pathway are destabilized rapidly upon its restitution.在缺乏功能性无义介导的mRNA降解途径时积累的含无义密码子的mRNA，在该途径恢复后会迅速变得不稳定。
Mol Cell Biol. 2003 Feb;23(3):842-51. doi: 10.1128/MCB.23.3.842-851.2003.
9
The tRNA-Tyr gene family of Saccharomyces cerevisiae: agents of phenotypic variation and position effects on mutation frequency.酿酒酵母的tRNA-Tyr基因家族：表型变异的因素及对突变频率的位置效应
Genetics. 2002 Aug;161(4):1395-410. doi: 10.1093/genetics/161.4.1395.
10
Gene cloning and functional characterization by heterologous expression of the fructosyltransferase of Aspergillus sydowi IAM 2544.米曲霉IAM 2544果糖基转移酶的基因克隆及通过异源表达进行功能表征
Appl Environ Microbiol. 2001 Jan;67(1):363-70. doi: 10.1128/AEM.67.1.363-370.2001.
Genetics. 1981 May;98(1):41-54. doi: 10.1093/genetics/98.1.41.
4
Structure of a split yeast gene: complete nucleotide sequence of the actin gene in Saccharomyces cerevisiae.一个分裂酵母基因的结构：酿酒酵母肌动蛋白基因的完整核苷酸序列。
Proc Natl Acad Sci U S A. 1980 May;77(5):2546-50. doi: 10.1073/pnas.77.5.2546.
5
Usage of the three termination codons: compilation and analysis of the known eukaryotic and prokaryotic translation termination sequences.三种终止密码子的使用：已知真核生物和原核生物翻译终止序列的汇编与分析
Mol Gen Genet. 1981;182(3):430-9. doi: 10.1007/BF00293932.
6
Messenger RNA stability in Saccharomyces cerevisiae: the influence of translation and poly(A) tail length.酿酒酵母中的信使核糖核酸稳定性：翻译和聚腺苷酸尾长度的影响
Nucleic Acids Res. 1987 Mar 25;15(6):2417-29. doi: 10.1093/nar/15.6.2417.
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Nonsense mutations in the human beta-globin gene affect mRNA metabolism.人类β-珠蛋白基因中的无义突变会影响mRNA代谢。
Proc Natl Acad Sci U S A. 1988 Apr;85(7):2056-60. doi: 10.1073/pnas.85.7.2056.
8
The effects of alterations within the 3' untranslated region of the pyruvate kinase messenger RNA upon its stability and translation in Saccharomyces cerevisiae.丙酮酸激酶信使核糖核酸3'非翻译区内的改变对其在酿酒酵母中的稳定性和翻译的影响。
Nucleic Acids Res. 1987 Oct 12;15(19):7951-62. doi: 10.1093/nar/15.19.7951.
9
Autoregulated instability of tubulin mRNAs: a novel eukaryotic regulatory mechanism.
Trends Biochem Sci. 1988 Sep;13(9):339-43. doi: 10.1016/0968-0004(88)90103-x.
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Messenger RNA degradation in Saccharomyces cerevisiae.酿酒酵母中的信使核糖核酸降解
Gene. 1988 Dec 10;72(1-2):151-60. doi: 10.1016/0378-1119(88)90137-0.