Department of Immunology & Microbiology, School of Medicine, Arak University of Medical Sciences, Arak, Iran.
Traditional and Complementary Medicine Research Center (TCMRC), Arak University of Medical Sciences, Arak, Iran.
Mol Biol Rep. 2022 Nov;49(11):10689-10702. doi: 10.1007/s11033-022-07695-5. Epub 2022 Jun 25.
Polycystic ovary syndrome (PCOS) is a common disorder of the endocrine system. Its main manifestations include oligo-ovulation, hyperandrogenism, and polycystic ovary morphology (PCOM), affecting women of childbearing age. Although the exact pathogenesis of this disease is still unknown, many factors, including genetic, endocrine, and metabolism disorders, play critical roles in its development. The immunopathogenesis of PCOS has not yet been studied in-depth, but it is hypothesized that immune system abnormalities may play a key role in it. Recent research has shown inflammation's effect on ovulation and ovarian follicular dynamics. Thus, it is suggested that there is a close association between PCOS and low-grade chronic systemic inflammation. As a result, chronic low-grade inflammation is identified as a significant factor in the pathogenesis and development of PCOS, which in turn leads to infertility. As a result, this article reviews PCOS immunopathology, evaluates long-standing hypotheses about the immune system's role in PCOS, and assesses the association between inflammatory factors and PCOS.
多囊卵巢综合征（PCOS）是一种常见的内分泌系统疾病。其主要表现为稀发排卵、高雄激素血症和多囊卵巢形态学改变（PCOM），影响育龄期妇女。尽管该病的确切发病机制尚不清楚，但许多因素，包括遗传、内分泌和代谢紊乱，在其发病过程中起关键作用。PCOS 的免疫发病机制尚未深入研究，但有假说认为免疫系统异常可能在其中起关键作用。最近的研究表明炎症对排卵和卵巢卵泡动力学的影响。因此，有人认为 PCOS 与低度慢性全身炎症之间存在密切关联。因此，慢性低度炎症被确定为 PCOS 发病机制和发展的重要因素，进而导致不孕。因此，本文综述了 PCOS 的免疫病理学，评估了关于免疫系统在 PCOS 中作用的长期假说，并评估了炎症因子与 PCOS 之间的关系。
