Lurie Center for Autism, Massachusetts General Hospital and Harvard Medical School, One Maguire Road, Lexington, MA 02421, USA.
J Autism Dev Disord. 2013 Jul;43(7):1623-9. doi: 10.1007/s10803-012-1709-3.
We determined whether bone mineral density (BMD) is lower in boys with autism spectrum disorders (ASD) than controls, and also assessed variables that may affect BMD in ASD. BMD was measured using dual energy X-ray absorptiometry (DXA) in 18 boys with ASD and 19 controls 8-14 years old. Boys with ASD had lower BMD Z-scores at the spine, hip and femoral neck, and differences at the hip and femoral neck persisted after controlling for maturity and BMI. Vitamin D intake from food and in serum were lower in ASD subjects, as was exercise activity. We conclude that BMD is lower in peripubertal boys with ASD and may be associated with impaired vitamin D status and lower exercise activity.
我们确定患有自闭症谱系障碍（ASD）的男孩的骨密度（BMD）是否低于对照组，并评估了可能影响 ASD 中 BMD 的变量。使用双能 X 射线吸收法（DXA）测量了 18 名 ASD 男孩和 19 名 8-14 岁的对照组男孩的 BMD。ASD 男孩的脊柱、臀部和股骨颈的 BMD Z 评分较低，在控制成熟度和 BMI 后，臀部和股骨颈的差异仍然存在。ASD 受试者的食物和血清中的维生素 D 摄入量较低，运动活动也较少。我们得出结论，青春期前 ASD 男孩的 BMD 较低，可能与维生素 D 状态受损和运动活动减少有关。
