Stem Cell Biology Group, Biological Therapies Program, Mater Medical Research Institute, South Brisbane, Australia.
Bioessays. 2013 Mar;35(3):183-90. doi: 10.1002/bies.201200111. Epub 2012 Nov 5.
Stem cells and their malignant counterparts require the support of a specific microenvironment or "niche". While various anti-cancer therapies have been broadly successful, there are growing opportunities to target the environment in which these cells reside to further improve therapeutic efficacy and outcome. This is particularly true when the aim is to target normal or malignant stem cells. The field aiming to target or use the niches that harbor, protect, and support stem cells could be designated as "nichotherapy". In this essay, we provide a few examples of nichotherapies. Some have been employed for decades, such as hematopoietic stem cell mobilization, whereas others are emerging, such as chemosensitization of leukemia stem cells by targeting their niche.
干细胞及其恶性对应物需要特定的微环境或“生态位”的支持。虽然各种抗癌疗法已广泛取得成功，但现在有越来越多的机会针对这些细胞所在的环境进行靶向治疗，以进一步提高治疗效果和结果。当目标是针对正常或恶性干细胞时，这一点尤其正确。旨在针对或利用容纳、保护和支持干细胞的生态位的领域可以被指定为“生态位治疗”。在这篇文章中，我们提供了一些生态位治疗的例子。有些已经使用了几十年，例如造血干细胞动员，而另一些则是新兴的，例如通过靶向白血病干细胞的生态位来增敏白血病干细胞的化疗。
