中国慢性乙型肝炎表面抗原携带者的乙肝e抗原阳性血清中乙肝病毒DNA的缺失情况。

The absence of hepatitis B virus DNA in hepatitis B e antigen positive sera from chronic hepatitis B surface antigen carriers in China.

作者信息

Scott J S, Pan P E, Pace R A, Sloots T P, Cooksley W G

机构信息

Department of Biochemistry, University of Queensland, Royal Brisbane Hospital, Australia.

出版信息

J Med Virol. 1990 Feb;30(2):103-6. doi: 10.1002/jmv.1890300205.

DOI:10.1002/jmv.1890300205

PMID:2313271

Abstract

Sera from 20 Chinese patients with chronic hepatitis B were examined for hepatitis B e antigen and hepatitis B virus (HBV) DNA. There was considerable discordance with HBV DNA not being detectable in 10 out of 13 (77%) patients who were hepatitis B e antigen positive. Further testing for anti-HBe and HBV-DNA polymerase activity confirmed the results. Possible reasons for this discordance are discussed but neither hepatitis D (delta) infection nor the acquired immunodeficiency syndrome (AIDS) could be implicated.

摘要

对20名中国慢性乙型肝炎患者的血清进行了乙肝e抗原和乙肝病毒（HBV）DNA检测。结果存在相当大的不一致性，在13名（77%）乙肝e抗原阳性患者中，有10名检测不到HBV DNA。对抗-HBe和HBV-DNA聚合酶活性的进一步检测证实了这些结果。文中讨论了这种不一致性的可能原因，但未发现与丁型肝炎（δ型肝炎）感染或获得性免疫缺陷综合征（艾滋病）有关。