Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Gut Microbes. 2013 Jan-Feb;4(1):76-83. doi: 10.4161/gmic.22759. Epub 2012 Nov 8.
Commensal bacteria that colonize mammalian mucosal surfaces are reported to influence T helper type 2 (TH 2) cytokine-dependent inflammation and susceptibility to allergic disease. However, the mechanisms that underlie these observations are only beginning to be understood. We recently utilized studies of murine model systems and atopic patient populations to elucidate a mechanism by which commensal bacteria-derived signals limit serum immunoglobulin E levels, influence basophil development and steady-state circulating basophil populations and regulate basophil-associated TH 2 cell responses and allergic inflammation. In this addendum, we summarize the findings of our recent work and other developments in the field, discuss the broader implications of these findings and generate new hypotheses regarding our understanding of host-commensal relationships. These areas of investigation may be applicable to the development of new preventative or therapeutic approaches to reduce the burden of allergic disease.
定植于哺乳动物黏膜表面的共生菌被报道可影响辅助性 T 细胞 2（TH2）细胞因子依赖性炎症和过敏性疾病的易感性。然而，这些观察结果背后的机制才刚刚开始被理解。我们最近利用鼠模型系统和特应性患者群体的研究，阐明了共生菌衍生信号限制血清免疫球蛋白 E 水平、影响嗜碱性粒细胞发育和稳态循环嗜碱性粒细胞群体以及调节嗜碱性粒细胞相关 TH2 细胞反应和过敏性炎症的机制。在本增刊中，我们总结了我们最近的工作和该领域其他进展的发现，讨论了这些发现的更广泛意义，并就我们对宿主-共生关系的理解提出了新的假设。这些研究领域可能适用于开发新的预防或治疗方法来减轻过敏性疾病的负担。
