School of Engineering and Department of Orthopedics, Brown University, Providence, RI 02912, USA.
Nanotechnology. 2012 Dec 7;23(48):485105. doi: 10.1088/0957-4484/23/48/485105. Epub 2012 Nov 9.
Magnesium has attracted some attention in orthopedics due to its biodegradability and mechanical properties. Since magnesium is an essential natural mineral for bone growth, it can be expected that as a biomaterial, it would support bone formation. However, upon degradation in the body, magnesium releases OH(-) which results in an alkaline pH that can be detrimental to cell density (for example, osteoblasts or bone forming cells). For this reason, modification of magnesium may be necessary to compensate for such detrimental effects to cells. This study created biologically inspired nanoscale surface features on magnesium by soaking magnesium in various concentrations of NaOH (from 1 to 10 N) and for various periods of time (from 10 to 30 min). The results provided the first evidence of increased roughness, surface energy, and consequently greater osteoblast adhesion, after 4 h as well as density up to 7 days on magnesium treated with any concentration of NaOH for any length of time compared to untreated controls. For these reasons, this study suggests that soaking magnesium in NaOH could be an inexpensive, simple and effective manner to promote osteoblast functions for numerous orthopedic applications and, thus, should be further studied.
镁因其可生物降解性和机械性能而在骨科领域引起了关注。由于镁是骨骼生长所必需的天然矿物质，因此可以预期作为生物材料，它将支持骨形成。然而，在体内降解时，镁会释放出 OH(-)，导致碱性 pH 值，这可能对细胞密度（例如成骨细胞或骨形成细胞）有害。出于这个原因，可能需要对镁进行改性以补偿对细胞的这种有害影响。本研究通过将镁浸泡在不同浓度的 NaOH（从 1 到 10 N）和不同时间（从 10 到 30 分钟）中，在镁上制造出受生物启发的纳米级表面特征。结果首次提供了证据，表明在镁上处理任何浓度的 NaOH 4 小时后以及高达 7 天的时间内，镁的粗糙度、表面能增加，从而成骨细胞黏附性增加，与未处理的对照相比。出于这些原因，本研究表明，将镁浸泡在 NaOH 中可能是一种廉价、简单且有效的方法，可以促进众多骨科应用中成骨细胞的功能，因此应进一步研究。
