Yeo In-Sung, Kim Ha-Young, Lim Kyung Sub, Han Jung-Suk
Department of Prosthodontics, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Korea.
Int J Artif Organs. 2012 Oct;35(10):762-72. doi: 10.5301/ijao.5000154.
The microbiota that forms on implant surfaces placed in the human body can be highly resistant to antimicrobial agents and in some cases cause life-threatening infections. Consequently, to limit bacterial attachment to these surfaces and thereby minimize the risk of implant infection, the process of biofilm formation and bacterial attachment must be well-understood. The oral environment is considered to be an excellent model for research into biofilm formation and implant infection, accounting for many studies carried out in the field of dental medicine. Those studies show that the roughness, free energy, and material characteristics of the implant surface largely determine initial bacterial adhesion. This article reviews the relevant literature on these aspects of biofilm formation.
植入人体的植入物表面形成的微生物群可能对抗菌剂具有高度抗性，在某些情况下会导致危及生命的感染。因此，为了限制细菌附着在这些表面上，从而将植入物感染的风险降至最低，必须充分了解生物膜形成和细菌附着的过程。口腔环境被认为是研究生物膜形成和植入物感染的理想模型，牙科医学领域已经开展了许多相关研究。这些研究表明，植入物表面的粗糙度、自由能和材料特性在很大程度上决定了细菌的初始黏附。本文综述了关于生物膜形成这些方面的相关文献。
