Charalampakis Georgios, Belibasakis Georgios N
a Department of Oral Microbiology and Immunology; Institute of Odontology, Gothenburg University; The Sahlgrenska Academy at University of Gothenburg ; Gothenburg , Sweden.
Virulence. 2015;6(3):183-7. doi: 10.4161/21505594.2014.980661. Epub 2015 Feb 5.
Osseointegrated dental implants are now a well-established treatment option in the armament of restorative dentistry. These technologically advanced devices are designed to functionally and esthetically replace missing teeth. Despite the revolutionary advances that implants have incurred, they have also provided the oral cavity with new artificial surfaces prone to the formation of oral biofilms, similarly to the hard tissue surfaces of natural teeth. Biofilm formation on the implant surface can trigger the inflammatory destruction of the peri-implant tissue, in what is known as peri-implantitis. The mixed microbial flora of peri-implant infections resembles that of periodontal infections, with some notable differences. These are likely to expand with the ever increasing application of metagenomics and metatrascriptomics in the analysis of oral ecology. This review presents the wealth of knowledge we have gained from microbiological methods used in the characterization of peri-implant microflora and sheds light over potential new benefits, as well as limitations, of the new sequencing technology in our understanding of peri-implant disease pathogenesis.
骨结合式牙种植体现已成为修复牙科治疗手段中一种成熟的治疗选择。这些技术先进的装置旨在从功能和美观上替代缺失的牙齿。尽管种植体带来了革命性的进展，但它们也为口腔提供了新的易于形成口腔生物膜的人工表面，这与天然牙的硬组织表面类似。种植体表面生物膜的形成可引发种植体周围组织的炎性破坏，即种植体周炎。种植体周围感染的混合微生物群落与牙周感染的相似，但也存在一些显著差异。随着宏基因组学和宏转录组学在口腔生态分析中的应用不断增加，这些差异可能会进一步扩大。本综述介绍了我们通过用于表征种植体周围微生物群落的微生物学方法所获得的丰富知识，并阐明了新测序技术在我们理解种植体周围疾病发病机制方面的潜在新益处及局限性。
