Fyntanidou B, Grosomanidis V, Aidoni Z, Thoma G, Giakoumis M, Kiurzieva E, Skourtis C
Department of Anesthesiology and Intensive Care Medicine, AHEPA University Hospital, Thessaloniki, Greece.
Transplant Proc. 2012 Nov;44(9):2702-5. doi: 10.1016/j.transproceed.2012.09.012.
Brain death (BD) is defined as the total irreversible loss of brain stem function. According to the Greek legislation, BD diagnosis is based on clinical criteria that test brain stem function. Bispectral Index Scale (BIS), a parameter derived from a mathematical analysis of the electroengephalogram depicts brain activity. The aim of our study was to record BIS alterations in brain-dead patients.
Thirty-five brain dead patients according to the clinical criteria were included in this study. All patients were hemodynamically stable, normothermic, and normocapnic, free of oxygenation disturbances and electrolyte abnormalities. Continuous BIS monitoring (BIS XP, A-2000, Aspect Medical Systems, Newton, Mass, USA) was performed in all patients for periods ranging from 24 to 36 hours.
BIS values were 0 for the majority of the study period in all patients. However, in 23 patients the BIS value exceeded 30 for more than 30 minutes. This increase could not be attributed to any external stimulation.
BIS is a noninvasive, easily interpreted method to monitor cerebral activity. According to our results, BIS could be helpful in BD confirmation but cannot replace the valid clinical tests, which are consistent with Greek legislation for this diagnosis.
脑死亡（BD）被定义为脑干功能的完全不可逆丧失。根据希腊法律，BD的诊断基于检测脑干功能的临床标准。脑电双频指数（BIS）是一种从脑电图的数学分析中得出的参数，用于描述大脑活动。我们研究的目的是记录脑死亡患者的BIS变化。
本研究纳入了35例符合临床标准的脑死亡患者。所有患者血流动力学稳定，体温正常，二氧化碳分压正常，无氧合障碍和电解质异常。对所有患者进行连续24至36小时的BIS监测（BIS XP，A - 2000，Aspect Medical Systems，美国马萨诸塞州牛顿市）。
在所有患者的大部分研究期间，BIS值均为0。然而，在23例患者中，BIS值超过30的时间超过30分钟。这种升高不能归因于任何外部刺激。
BIS是一种监测大脑活动的非侵入性、易于解读的方法。根据我们的结果，BIS有助于BD的确认，但不能取代有效的临床检查，这与希腊关于该诊断的法律规定一致。
