School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom.
Antimicrob Agents Chemother. 2013 Jan;57(1):655-7. doi: 10.1128/AAC.01020-12. Epub 2012 Nov 12.
A Stenotrophomonas maltophilia mutant that coordinately hyper-expresses three resistance nodulation division-type efflux pump genes, smeZ, smeJ, and smeK, has been identified. SmeZ is responsible for elevating aminoglycoside MICs; SmeJ and SmeK are jointly responsible for elevating tetracycline, minocycline, and ciprofloxacin MICs and conferring levofloxacin resistance. One clinical isolate with this same phenotype was identified from a sample of six, and the isolate also coordinately hyper-expresses smeZ and smeJK, confirming the clinical relevance of our findings.
已鉴定出协同过表达三个抗性结节分裂型外排泵基因 smeZ、smeJ 和 smeK 的嗜麦芽寡养单胞菌突变体。SmeZ 负责提高氨基糖苷类药物 MIC;SmeJ 和 SmeK 共同负责提高四环素、米诺环素和环丙沙星 MIC 并赋予左氧氟沙星耐药性。从 6 份样本中鉴定出一个具有相同表型的临床分离株,该分离株也协同过表达 smeZ 和 smeJK,证实了我们研究结果的临床相关性。