Department of Internal Medicine, University Hospitals Leuven, Leuven, Belgium.
Lung. 2013 Feb;191(1):19-25. doi: 10.1007/s00408-012-9433-5. Epub 2012 Nov 13.
The term diffuse parenchymal lung disease (DPLD) refers to a group of disorders affecting the lung parenchyma that can be categorized into those of known and those of unknown etiology. Early diagnosis is important since some forms of DPLD are characterized by a rapid progression to respiratory failure. Notwithstanding the fact that recently guidelines have been published, some issues concerning the practical evaluation of a patient with suspected DPLD remain unclear.
In this article we propose a practical approach to the diagnosis and differentiation of DPLD. Moreover, a critical appraisal is provided based on the current literature and frequent pitfalls are highlighted.
we propose a practical workup, but in spite of increasing evidence concerning the diagnosis of DPLD, further studies will be needed to clarify several issues for efficient investigation of newly diagnosed patients with DPLD.
弥漫性实质性肺疾病（DPLD）是一组影响肺实质的疾病，可分为已知病因和未知病因两类。早期诊断很重要，因为某些形式的 DPLD 会迅速发展为呼吸衰竭。尽管最近已经发布了指南，但在疑似 DPLD 患者的实际评估中仍存在一些问题不清楚。
本文提出了一种实用的 DPLD 诊断和鉴别方法。此外，还根据当前文献进行了批判性评估，并强调了常见的陷阱。
我们提出了一种实用的工作流程，但尽管有关 DPLD 诊断的证据不断增加，仍需要进一步研究来阐明一些问题，以便对新诊断的 DPLD 患者进行有效的调查。
