与超声激活微泡相关的特征性微血管弛豫时间尺度。
Characteristic microvessel relaxation timescales associated with ultrasound-activated microbubbles.
作者信息
Chen Hong, Brayman Andrew A, Matula Thomas J
机构信息
Center for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, Seattle, Washington 98105, USA.
出版信息
Appl Phys Lett. 2012 Oct 15;101(16):163704. doi: 10.1063/1.4761937. Epub 2012 Oct 19.
Ultrasound-activated microbubbles were used as actuators to deform microvessels for quantifying microvessel relaxation timescales at megahertz frequencies. Venules containing ultrasound contrast microbubbles were insonified by short 1 MHz ultrasound pulses. Vessel wall forced-deformations were on the same microsecond timescale as microbubble oscillations. The subsequent relaxation of the vessel was recorded by high-speed photomicrography. The tissue was modeled as a simple Voigt solid. Relaxation time constants were measured to be on the order of ∼10 μs. The correlation coefficients between the model and 38 data sets were never lower than 0.85, suggesting this model is sufficient for modeling tissue relaxation at these frequencies. The results place a bound on potential numerical values for viscosity and elasticity of venules.
超声激活微泡被用作致动器，使微血管变形，以量化兆赫兹频率下微血管的弛豫时间尺度。含有超声造影微泡的微静脉由1兆赫兹的短超声脉冲进行超声照射。血管壁的强制变形与微泡振荡处于相同的微秒时间尺度。随后通过高速显微摄影记录血管的弛豫过程。该组织被建模为一个简单的沃伊特固体。测得的弛豫时间常数约为10微秒量级。该模型与38个数据集之间的相关系数从未低于0.85，表明该模型足以对这些频率下的组织弛豫进行建模。这些结果为微静脉的粘度和弹性的潜在数值设定了界限。
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