First Affiliated Hospital, Medical College of Shantou University, Shantou 515041, China.
Clin Imaging. 2012 Nov-Dec;36(6):695-701. doi: 10.1016/j.clinimag.2012.02.006. Epub 2012 Jun 8.
The study aimed to explore the abnormal activation of special brain areas associated with methamphetamine craving using functional magnetic resonance imaging (fMRI) and to reveal the neurobiological basis of addiction. Twenty-six methamphetamine addicts and 26 healthy subjects were scanned by brain fMRI while watching pictures of happy, sad, or methamphetamine to acquire resource data. SPM5 was used to analyze fMRI data to get related brain activation map, and it was found that methamphetamine addicts had high brain activation in cingulate and low activation in frontal lobe when watching methamphetamine-cue pictures. This study demonstrated that methamphetamine addicts had emotion-related brain activation abnormalities.
该研究旨在利用功能磁共振成像（fMRI）探索与甲基苯丙胺渴望相关的特殊脑区的异常激活，并揭示成瘾的神经生物学基础。26名甲基苯丙胺成瘾者和26名健康受试者在观看快乐、悲伤或甲基苯丙胺图片时接受脑部fMRI扫描，以获取源数据。使用SPM5分析fMRI数据以获得相关脑激活图，结果发现甲基苯丙胺成瘾者在观看甲基苯丙胺提示图片时扣带回脑激活较高，而额叶激活较低。这项研究表明甲基苯丙胺成瘾者存在与情绪相关的脑激活异常。
