Naveh N, Weissman C
Maurice and Gabriela Goldschleger Eye Research Institute, Chaim Sheba Medical Center, Tel Hashomer, Israel.
Prostaglandins. 1990 Feb;39(2):147-56. doi: 10.1016/0090-6980(90)90071-3.
Changes in vitreal protein and prostaglandin E2 (PGE2) concentrations, as well as chorioretinal in vitro PGE2 production, were studied in rabbit eyes following Neodymium (Nd):YAG laser retinal exposure. Laser exposure was associated with an enhanced vitreal PGE2 concentration throughout a two-week observation period, with highest levels on days 1 and 7 after exposure (a 5.3 and 4.7 increase above baseline, respectively). A transitory 50% elevation above baseline in vitreal protein levels was observed in the laser-exposed eyes during the second week after exposure. Laser exposure was also associated with an enhancement in the in vitro chorioretinal PGE2 production, which varied throughout the observation period, and was more pronounced during the first week after exposure, when levels were four times higher than baseline. Initially PGE2 vitreal levels were closely related to excessive in vitro production. However, during the second week after exposure, evidence of such correlation was lacking, but PGE2 vitreal levels coincided with a small increase in vitreal protein levels. It is suggested that disruption of the blood retinal barrier by the long-term exposure to mildly elevated vitreal PGE2 levels was accountable for protein leakage, which might have affected PGE2 removal mechanisms.
在钕（Nd）：YAG激光视网膜照射后的兔眼中，研究了玻璃体内蛋白质和前列腺素E2（PGE2）浓度的变化以及脉络膜视网膜体外PGE2的产生。在整个两周的观察期内，激光照射与玻璃体内PGE2浓度升高有关，在照射后第1天和第7天达到最高水平（分别比基线增加5.3和4.7）。在照射后第二周，激光照射的眼睛中观察到玻璃体内蛋白质水平短暂升高至基线以上50%。激光照射还与脉络膜视网膜体外PGE2产生的增强有关，其在整个观察期内有所变化，在照射后第一周更为明显，此时水平比基线高四倍。最初，玻璃体内PGE2水平与体外过度产生密切相关。然而，在照射后第二周，缺乏这种相关性的证据，但玻璃体内PGE2水平与玻璃体内蛋白质水平的小幅增加一致。有人认为，长期暴露于轻度升高的玻璃体内PGE2水平导致血视网膜屏障破坏是蛋白质渗漏的原因，这可能影响了PGE2的清除机制。
