O'Callaghan C
Department of Child Health, University Hospital, Nottingham.
Thorax. 1990 Feb;45(2):109-11. doi: 10.1136/thx.45.2.109.
An impactor method was used to assess the amount of beclomethasone dipropionate in particles less than 5 microns produced by two nebulisers (Pari Inhalierboy, Medix Traveller compressor with cirrhus nebuliser chamber) and two spacer devices (Volumatic and Nebuhaler). After nebulisation of 3 ml (150 micrograms) beclomethasone dipropionate the amount of drug in particles less than 5 microns was 16 micrograms (GSD 1.1) with the Pari Inhalierboy, and 27 micrograms (1.4) with the Medix Traveller with cirrhus nebuliser. This was less than the amount in particles less than 5 microns after three metered dose inhaler actuations (150 micrograms) from the Nebuhaler (58.2 (1) micrograms) or the Volumatic spacer (46.5 (1) micrograms). The greater amount of beclomethasone dipropionate in small particles with administration from a metered dose inhaler with a spacer device means that considerably more drug is likely to reach the airways than when the same dose is given by the two nebulisers studied.
采用撞击器法评估了两种雾化器（帕里吸入宝、配有Cirrhus雾化器腔的Medix Traveller压缩机）和两种储雾罐装置（Volumatic和Nebuhaler）产生的粒径小于5微米颗粒中丙酸倍氯米松的含量。雾化3毫升（150微克）丙酸倍氯米松后，帕里吸入宝产生的粒径小于5微米颗粒中的药物含量为16微克（几何标准差1.1），配有Cirrhus雾化器的Medix Traveller产生的为27微克（1.4）。这低于从Nebuhaler（58.2（1）微克）或Volumatic储雾罐进行三次定量吸入器启动（150微克）后粒径小于5微米颗粒中的药物含量。使用配有储雾罐装置的定量吸入器给药时，小颗粒中丙酸倍氯米松的含量更高，这意味着与使用所研究的两种雾化器给予相同剂量相比，可能有更多药物到达气道。
