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雾化吸入丙酸倍氯米松治疗学龄前儿童哮喘

Nebulised beclomethasone dipropionate in preschool asthma.

作者信息

Storr J, Lenney C A, Lenney W

出版信息

Arch Dis Child. 1986 Mar;61(3):270-3. doi: 10.1136/adc.61.3.270.

DOI:10.1136/adc.61.3.270
PMID:3516078
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1777728/
Abstract

Twenty nine young children with severe recurrent asthma were given nebulised beclomethasone dipropionate or normal saline in a double blind manner over a six month period. Progress was monitored using diary score cards. Those receiving beclomethasone had lower symptom scores, had more symptom free days, and required less additional treatment with bronchodilator agents. The code needed to be broken more frequently if normal saline was used. Over the study period height and weight increases in the two groups were similar, and no serious side effects were noted.

摘要

29名患有严重复发性哮喘的幼儿在6个月的时间里以双盲方式接受了雾化丙酸倍氯米松或生理盐水治疗。使用日记评分卡监测进展情况。接受丙酸倍氯米松治疗的患儿症状评分较低,无症状天数更多,并且需要使用支气管扩张剂进行额外治疗的次数更少。如果使用生理盐水,则需要更频繁地破解密码。在研究期间,两组儿童的身高和体重增长相似,且未观察到严重的副作用。

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本文引用的文献

1
Sample size nomograms for interpreting negative clinical studies.用于解读阴性临床研究的样本量列线图。
Ann Intern Med. 1983 Aug;99(2):248-51. doi: 10.7326/0003-4819-99-2-248.
2
Seasonal variation and time trends in childhood asthma in England and Wales 1975-81.1975 - 1981年英格兰和威尔士儿童哮喘的季节性变化及时间趋势
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Treatment of childhood asthma for 13 months and longer with beclomethasone dipropionate aerosol.用丙酸倍氯米松气雾剂治疗儿童哮喘13个月及更长时间。
Arch Dis Child. 1974 Aug;49(8):591-6. doi: 10.1136/adc.49.8.591.
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A three- to five-year follow-up of the use of the aerosol steroid, beclomethasone dipropionate, in childhood asthma.丙酸倍氯米松气雾剂用于儿童哮喘的三至五年随访
J Allergy Clin Immunol. 1978 Dec;62(6):335-9. doi: 10.1016/0091-6749(78)90133-1.
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A clinical comparison of beclomethasone dipropionate delivered by pressurised aerosol and as a powder from a rotahaler.丙酸倍氯米松通过压力定量气雾剂和旋转式吸入器干粉给药的临床比较。
Arch Dis Child. 1979 Mar;54(3):233-5. doi: 10.1136/adc.54.3.233.