个体在精神病高危临床状态下认知功能的六个月变化过程。
The course of cognitive functioning over six months in individuals at clinical high risk for psychosis.
机构信息
Hotchkiss Brain Institute, Department of Psychiatry, University of Calgary, Alberta, Canada.
出版信息
Psychiatry Res. 2013 Apr 30;206(2-3):195-9. doi: 10.1016/j.psychres.2012.10.013. Epub 2012 Nov 16.
Abstract
Cognitive impairment is common in psychosis and has recently been observed in individuals at clinical high risk (CHR) of developing psychosis. The purpose of this study was to characterize longitudinal change in cognition among CHR individuals, and compare cognition of CHR individuals who later convert to psychosis to that of CHR who do not convert. Participants were tested at baseline and followed-up after six months using a comprehensive cognitive test battery. Individuals who did not convert to psychosis either remained stable or significantly improved in their cognitive performance. At baseline participants who converted to psychosis compared to non-converters exhibited poorer performance in several cognitive tests, suggesting that some cognitive impairment is already present before conversion. Future longitudinal research should address if further decline takes place during the prodrome or after conversion to psychosis.
摘要
认知障碍在精神疾病中很常见，最近在有发展为精神疾病临床高风险（CHR）的个体中也观察到了这种情况。本研究的目的是描述 CHR 个体认知的纵向变化，并比较后来发展为精神病的 CHR 个体和未发展为精神病的 CHR 个体的认知。参与者在基线时接受测试，并在六个月后使用综合认知测试工具进行随访。未发展为精神病的个体的认知表现要么保持稳定，要么显著改善。在基线时，与未转换者相比，转换为精神病的参与者在几项认知测试中表现较差，这表明在转换之前已经存在一些认知障碍。未来的纵向研究应该解决在前驱期或转换为精神病后是否会进一步下降的问题。
相似文献
1
The course of cognitive functioning over six months in individuals at clinical high risk for psychosis.个体在精神病高危临床状态下认知功能的六个月变化过程。
Psychiatry Res. 2013 Apr 30;206(2-3):195-9. doi: 10.1016/j.psychres.2012.10.013. Epub 2012 Nov 16.
2
Association of Neurocognition With Transition to Psychosis: Baseline Functioning in the Second Phase of the North American Prodrome Longitudinal Study.神经认知与向精神病转变的关联：北美前驱期纵向研究第二阶段的基线功能状况
JAMA Psychiatry. 2016 Dec 1;73(12):1239-1248. doi: 10.1001/jamapsychiatry.2016.2479.
3
Neuropsychology of the prodrome to psychosis in the NAPLS consortium: relationship to family history and conversion to psychosis.NAPLS联盟中精神病前驱期的神经心理学：与家族史及向精神病转化的关系
Arch Gen Psychiatry. 2010 Jun;67(6):578-88. doi: 10.1001/archgenpsychiatry.2010.66.
4
From the psychosis prodrome to the first-episode of psychosis: No evidence of a cognitive decline.从精神病前驱期到精神病首次发作：没有认知能力下降的证据。
J Psychiatr Res. 2018 Jan;96:231-238. doi: 10.1016/j.jpsychires.2017.10.014. Epub 2017 Oct 19.
5
Predicting psychosis risk using a specific measure of cognitive control: a 12-month longitudinal study.使用认知控制的特定测量方法预测精神病风险：一项为期12个月的纵向研究。
Psychol Med. 2020 Oct;50(13):2230-2239. doi: 10.1017/S0033291719002332. Epub 2019 Sep 11.
6
The role of cognitive functioning in the outcome of those at clinical high risk for developing psychosis.认知功能在那些处于精神病发病临床高风险的人群中的作用。
Epidemiol Psychiatr Sci. 2012 Dec;21(4):335-42. doi: 10.1017/S204579601200042X.
7
Changes in the cognitive function of Chinese college students with a clinical high risk of psychosis.中文大学生精神病高危人群认知功能的变化。
Psychiatry Res. 2021 Nov;305:114242. doi: 10.1016/j.psychres.2021.114242. Epub 2021 Oct 11.
8
Various neurocognitive deficits and conversion risk in individuals at clinical high risk for psychosis.临床高危精神病个体的各种神经认知缺陷及转化风险。
Early Interv Psychiatry. 2017 Jun;11(3):250-254. doi: 10.1111/eip.12296. Epub 2015 Dec 10.
9
Affect recognition in people at clinical high risk of psychosis.精神病高危人群的情感识别。
Schizophr Res. 2012 Sep;140(1-3):87-92. doi: 10.1016/j.schres.2012.06.012. Epub 2012 Jul 3.
10
The impact of psychosis on the course of cognition: a prospective, nested case-control study in individuals at clinical high-risk for psychosis.精神病对认知过程的影响：一项针对临床高危精神病个体的前瞻性巢式病例对照研究。
Psychol Med. 2015 Nov;45(15):3341-54. doi: 10.1017/S0033291715001233. Epub 2015 Jul 14.
引用本文的文献
1
Longitudinal change in neurocognitive functioning in children and adolescents at clinical high risk for psychosis: a systematic review.儿童和青少年精神病临床高危人群的神经认知功能的纵向变化：系统综述。
Eur Child Adolesc Psychiatry. 2024 Oct;33(10):3377-3387. doi: 10.1007/s00787-023-02221-9. Epub 2023 May 18.
2
Associations between symptom and neurocognitive dimensions in clinical high risk for psychosis.精神病临床高危状态下症状与神经认知维度之间的关联。
Schizophr Res Cogn. 2022 Jun 2;29:100260. doi: 10.1016/j.scog.2022.100260. eCollection 2022 Sep.
3
A systematic review of premorbid cognitive functioning and its timing of onset in schizophrenia spectrum disorders.对精神分裂症谱系障碍病前认知功能及其发病时间的系统评价。
Schizophr Res Cogn. 2022 Mar 1;28:100246. doi: 10.1016/j.scog.2022.100246. eCollection 2022 Jun.
4
Sleep, sleep spindles, and cognitive functions in drug-naive patients with first-episode psychosis.睡眠、睡眠纺锤波与首发精神病患者认知功能的关系。
J Clin Sleep Med. 2020 Dec 15;16(12):2079-2087. doi: 10.5664/jcsm.8776.
5
Global and Specific Profiles of Executive Functioning in Prodromal and Early Psychosis.前驱期和早期精神病中执行功能的整体及特定概况
Front Psychiatry. 2019 May 21;10:356. doi: 10.3389/fpsyt.2019.00356. eCollection 2019.
6
Longitudinal Cognitive Performance in Individuals at Ultrahigh Risk for Psychosis: A 10-year Follow-up.超高精神病风险个体的纵向认知表现：10 年随访研究。
Schizophr Bull. 2019 Sep 11;45(5):1101-1111. doi: 10.1093/schbul/sby143.
7
Neuropsychological Impairment in Prodromal, First-Episode, and Chronic Psychosis: Assessing RBANS Performance.前驱期、首发及慢性精神病中的神经心理损害：评估RBANS表现
PLoS One. 2015 May 14;10(5):e0125784. doi: 10.1371/journal.pone.0125784. eCollection 2015.
8
Exploratory analysis of social cognition and neurocognition in individuals at clinical high risk for psychosis.探索性分析处于精神病临床高风险个体的社会认知和神经认知。
Psychiatry Res. 2014 Aug 15;218(1-2):39-43. doi: 10.1016/j.psychres.2014.04.003. Epub 2014 Apr 12.
9
Meta-analysis of cognitive deficits in ultra-high risk to psychosis and first-episode psychosis: do the cognitive deficits progress over, or after, the onset of psychosis?超高危精神病状态和首发精神病认知缺陷的荟萃分析：认知缺陷是在精神病发作期间还是之后进展？
Schizophr Bull. 2014 Jul;40(4):744-55. doi: 10.1093/schbul/sbt085. Epub 2013 Jun 14.
10
Change in neuropsychological functioning over one year in youth at clinical high risk for psychosis.青少年精神病临床高危人群一年间神经心理学功能的变化。
Schizophr Res. 2013 May;146(1-3):87-94. doi: 10.1016/j.schres.2013.01.017. Epub 2013 Feb 22.
本文引用的文献
1
The role of cognitive functioning in the outcome of those at clinical high risk for developing psychosis.认知功能在那些处于精神病发病临床高风险的人群中的作用。
Epidemiol Psychiatr Sci. 2012 Dec;21(4):335-42. doi: 10.1017/S204579601200042X.
2
Cognitive functioning in prodromal psychosis: a meta-analysis.前驱期精神病的认知功能：一项荟萃分析。
Arch Gen Psychiatry. 2012 Jun;69(6):562-71. doi: 10.1001/archgenpsychiatry.2011.1592.
3
Neurocognition in the psychosis risk syndrome: a quantitative and qualitative review.精神病风险综合征的神经认知：定量和定性综述。
Curr Pharm Des. 2012;18(4):399-415. doi: 10.2174/138161212799316019.
4
Prediction and prevention of psychosis in youth at clinical high risk.青年临床高危人群精神病的预测与预防。
Annu Rev Clin Psychol. 2012;8:269-89. doi: 10.1146/annurev-clinpsy-032511-143146. Epub 2011 Dec 12.
5
Circumstances under which practice does not make perfect: a review of the practice effect literature in schizophrenia and its relevance to clinical treatment studies.不完美实践的情况：精神分裂症实践效应文献综述及其与临床治疗研究的相关性。
Neuropsychopharmacology. 2010 Apr;35(5):1053-62. doi: 10.1038/npp.2009.211. Epub 2010 Jan 20.
6
Neurocognition in first-episode schizophrenia: a meta-analytic review.首发精神分裂症的神经认知：一项荟萃分析综述
Neuropsychology. 2009 May;23(3):315-36. doi: 10.1037/a0014708.
7
Verbal working memory impairments in individuals with schizophrenia and their first-degree relatives: findings from the Consortium on the Genetics of Schizophrenia.精神分裂症患者及其一级亲属的言语工作记忆损害：精神分裂症遗传学联盟的研究结果。
Schizophr Res. 2008 Aug;103(1-3):218-28. doi: 10.1016/j.schres.2008.02.014. Epub 2008 Apr 11.
8
Generalized and specific cognitive performance in clinical high-risk cohorts: a review highlighting potential vulnerability markers for psychosis.临床高危人群的一般和特定认知表现：一项强调精神病潜在易损性标志物的综述。
Schizophr Bull. 2006 Jul;32(3):538-55. doi: 10.1093/schbul/sbj077. Epub 2006 Jun 16.
9
Short- and long-term spatial delayed response performance across the lifespan.一生中短期和长期空间延迟反应表现。
Dev Neuropsychol. 2004;26(3):661-78. doi: 10.1207/s15326942dn2603_1.
10
Letter and category fluency in schizophrenic patients: a meta-analysis.精神分裂症患者的字母流畅性和类别流畅性：一项荟萃分析。
Schizophr Res. 2003 Nov 1;64(1):73-8. doi: 10.1016/s0920-9964(02)00282-7.
Zotero 插件