Wuhan Wuchang Hospital, Wuchang Hospital Affiliated to Wuhan University of Science and Technology, Wuhan 430000, China.
Wuhan Wuchang Hospital, Wuchang Hospital Affiliated to Wuhan University of Science and Technology, Wuhan 430000, China.
Psychiatry Res. 2021 Nov;305:114242. doi: 10.1016/j.psychres.2021.114242. Epub 2021 Oct 11.
The purpose of our study was to explore the value of measuring cognitive functions for predicting the conversion to psychosis in Chinese college students with a clinical high risk (CHR). A total of 115 CHR students and 99 healthy controls were enrolled. All included participants were recruited from colleges in Wuhan, China. The MATRICS Consensus Cognitive Battery was used to evaluate cognitive function. CHR individuals were followed for 2 years, and the cognitive function of CHR individuals who later converted to psychosis (CHR-C) was compared to CHR individuals who did not convert (CHR-NC). Of the 107 CHR individuals that completed the 2- year follow-up, 29 (27.1%) developed a psychotic disorder. CHR individuals demonstrated poorer performance on all cognitive function tests compared to controls. CHR-C participants exhibited poorer performance on all cognitive tests except the Trail Making Test A and Continuous Performance Test-Identical Pairs compared to CHR-NC participants. The most significant differences displayed between CHR-C and CHR-NC groups were in visual learning, working memory, and reasoning and problem solving. The degree of cognitive impairment in visual learning and working memory may be a predictive marker for individuals who are at risk of developing psychosis.
我们的研究目的是探索测量认知功能对预测中国有临床高风险（CHR）的大学生向精神病转化的价值。共纳入 115 名 CHR 学生和 99 名健康对照者。所有纳入的参与者均来自中国武汉的高校。采用 MATRICS 共识认知电池评估认知功能。对 CHR 个体进行了 2 年的随访，比较了后来转为精神病（CHR-C）的 CHR 个体和未转为精神病（CHR-NC）的 CHR 个体的认知功能。在完成 2 年随访的 107 名 CHR 个体中，29 名（27.1%）发展为精神障碍。与对照组相比，CHR 个体在所有认知功能测试中表现较差。与 CHR-NC 参与者相比，CHR-C 参与者在除连线测试 A 和连续性能测试-相同对之外的所有认知测试中表现较差。CHR-C 和 CHR-NC 组之间显示的最显著差异是在视觉学习、工作记忆、推理和解决问题方面。视觉学习和工作记忆方面的认知障碍程度可能是个体发生精神病风险的预测指标。
