Wang Dan, Lin Bingbing, Ai Hua
National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 610064, People's Republic of China.
Pharm Res. 2014 Jun;31(6):1390-406. doi: 10.1007/s11095-013-1277-z. Epub 2014 Mar 5.
Theranostics have received enormous attentions for individualized diagnosis and treatment in the past few years. Especially, the availability of various nanoplatforms provides great potentials for designing of sophisticated theranostic agents including imaging, targeting and therapeutic functions. Numerous reports have been published on how to construct multifunctional nanoparticles for the targeted diagnosis and therapy simultaneously since the concept of "theranostics". This review presents recent advances of molecular imaging and nanoplatform technology, and their applications in drug discovery and development. Applications of nanoplatform-based theranostics in cancer and cardiovascular diseases will also be covered including diagnosis, assessment of drug biodistribution, and visualization of drug release from nanoparticles, as well as monitoring of therapeutic effects.
在过去几年中，诊疗一体化在个性化诊断和治疗方面受到了极大关注。特别是，各种纳米平台的出现为设计复杂的诊疗试剂（包括成像、靶向和治疗功能）提供了巨大潜力。自“诊疗一体化”概念提出以来，已有大量关于如何构建多功能纳米颗粒以同时实现靶向诊断和治疗的报道。本文综述了分子成像和纳米平台技术的最新进展及其在药物发现与开发中的应用。还将介绍基于纳米平台的诊疗一体化在癌症和心血管疾病中的应用，包括诊断、药物生物分布评估、纳米颗粒药物释放可视化以及治疗效果监测。
