Center for Systems Biology, Harvard Medical School, Massachusetts General Hospital, Charlestown, 02129, USA.
Adv Drug Deliv Rev. 2010 Aug 30;62(11):1023-30. doi: 10.1016/j.addr.2010.07.004. Epub 2010 Jul 21.
The development of agents for the simultaneous detection and treatment of disease has recently gained significant attention. These multifunctional theranostic agents posses a number of advantages over their monofunctional counterparts, as they potentially allow for the concomitant determination of agent localization, release, and efficacy. Whereas the development of these agents for use in cancers has received the majority of the attention, their use in cardiovascular disease is steadily increasing. As such, this review summarized some of the most poignant recent advances in the development of theranostic agents for the treatment of this class of diseases.
近年来，同时检测和治疗疾病的试剂的发展受到了广泛关注。与单功能试剂相比，这些多功能治疗试剂具有许多优势，因为它们有可能同时确定试剂的定位、释放和疗效。尽管这些试剂在癌症治疗中的应用受到了大多数关注，但它们在心血管疾病中的应用也在稳步增加。因此，本文总结了一些最近在治疗这类疾病的治疗试剂开发方面的重要进展。
