Department of Chemical and Biological Engineering, Chalmers University of Technology, SE-41296 Gothenburg, Sweden.
Metab Eng. 2013 Jan;15:48-54. doi: 10.1016/j.ymben.2012.11.002. Epub 2012 Nov 17.
Production of fuels and chemicals by industrial biotechnology requires efficient, safe and flexible cell factory platforms that can be used for production of a wide range of compounds. Here we developed a platform yeast cell factory for efficient provision of acetyl-CoA that serves as precursor metabolite for a wide range of industrially interesting products. We demonstrate that the platform cell factory can be used to improve the production of α-santalene, a plant sesquiterpene that can be used as a perfume by four-fold. This strain would be a useful tool to produce a wide range of acetyl-CoA-derived products.
工业生物技术生产燃料和化学品需要高效、安全和灵活的细胞工厂平台，这些平台可用于生产广泛的化合物。在这里，我们开发了一种平台酵母细胞工厂，用于高效提供乙酰辅酶 A，乙酰辅酶 A 是广泛的工业感兴趣的产品的前体代谢物。我们证明该平台细胞工厂可用于提高植物倍半萜 α-檀香烯的产量，使其增加四倍。这种菌株将是生产广泛的乙酰辅酶 A 衍生产品的有用工具。
Zotero 插件