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皮肤转移作为甲状腺乳头状癌的首发症状。

Cutaneous metastasis as the presenting sign of papillary thyroid carcinoma.

作者信息

Somoza Arthur David, Bui Hai, Samaan Saad, Dhanda-Patil Reena, Mutasim Diya F

机构信息

Department of Pathology, University of Cincinnati College of Medicine, Cincinnati OH, USA.

出版信息

J Cutan Pathol. 2013 Feb;40(2):274-8. doi: 10.1111/cup.12044. Epub 2012 Nov 20.

Abstract

Cutaneous metastasis of visceral tumors accounts for 2% of skin tumors. We report the case of a 71-year-old male with a smoking history who presented to dermatology department with a violaceous nodule of the right sideburn skin. The lesion was interpreted as an adenocarcinoma that was completely excised and was suspicious for a metastasis. There was a recommendation for additional work-up. At a different institution, a positron emission tomography scan showed a left hilar mass and uptake in the right thyroid. He was then referred to our hospital for tissue diagnosis. Mediastinoscopy with biopsy of the left hilar mass showed metastatic follicular thyroid carcinoma. Subsequently, a thyroid fine needle aspirate showed suspicion for malignancy with similar morphology. Thyroidectomy and central neck dissection showed right thyroid papillary carcinoma extending to one margin and involving the lymph nodes. The left hilar metastasis mass resection showed similar lymph node findings. A re-review of the sideburn excision revealed similar histopathology to the thyroid and mediastinal resection. This case illustrates the opportunity of considering metastatic thyroid carcinoma to skin even in cases which lack the classic cytologic and architectural features of papillary thyroid carcinoma follicular variant.

摘要

内脏肿瘤的皮肤转移占皮肤肿瘤的2%。我们报告一例71岁有吸烟史的男性,因右侧鬓角皮肤出现一个紫红色结节就诊于皮肤科。该病变被诊断为腺癌,已完全切除,怀疑为转移瘤。建议进一步检查。在另一家机构,正电子发射断层扫描显示左肺门肿块及右侧甲状腺摄取。随后他被转诊至我院进行组织诊断。纵隔镜检查及左肺门肿块活检显示为转移性滤泡状甲状腺癌。随后,甲状腺细针穿刺显示怀疑为恶性肿瘤,形态相似。甲状腺切除术及中央区颈部清扫显示右侧甲状腺乳头状癌延伸至一侧边缘并累及淋巴结。左肺门转移肿块切除术显示类似的淋巴结表现。对鬓角切除标本的再次检查显示其组织病理学与甲状腺及纵隔切除标本相似。该病例表明,即使在缺乏甲状腺乳头状癌滤泡变体经典细胞学和结构特征的情况下,也应考虑甲状腺癌转移至皮肤的可能性。

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