Phelan Patrick S, Mull Jamie L, Rajput Mohamed Z, Musiek Amy C
Washington University in Saint Louis School of Medicine, Saint Louis, Missouri, USA.
Division of Dermatology, Washington University in Saint Louis School of Medicine, Saint Louis, Missouri, USA.
BMJ Case Rep. 2018 Jun 17;2018:bcr-2017-222552. doi: 10.1136/bcr-2017-222552.
We present the case of a 65-year-old man with severe headaches and unilateral facial weakness, seen in consultation by the dermatology service to rule out primary cutaneous melanoma after brain imaging identified an enlarging mass within the right trigeminal (Meckel's) cave. Examination revealed only a pair of erythematous papules on the scalp, for which biopsy demonstrated metastatic papillary thyroid carcinoma. Further evaluation and subsequent thyroidectomy confirmed the origin of widespread internal disease, followed by definitive excision of scalp lesions and multimodal management of systemic involvement. Whereas presentation of metastasis to the skin is highly variable, a low threshold for biopsy may allow for histological identification of internal disease not otherwise considered in the clinical differential.
我们报告了一例65岁男性患者,其患有严重头痛和单侧面部无力,在脑部成像发现右侧三叉神经(梅克尔)腔内有一不断增大的肿块后,皮肤科会诊以排除原发性皮肤黑色素瘤。检查仅发现头皮上有一对红斑丘疹,活检显示为转移性乳头状甲状腺癌。进一步评估及随后的甲状腺切除术证实了广泛的内部疾病的起源,随后对头皮病变进行了根治性切除,并对全身受累情况进行了多模式治疗。虽然皮肤转移的表现差异很大,但活检阈值较低可能有助于对临床上未考虑的内部疾病进行组织学鉴定。