Rodrigue D C, Etzel R A, Hall S, de Porras E, Velasquez O H, Tauxe R V, Kilbourne E M, Blake P A
Center for Infectious Diseases, Centers for Disease Control, Atlanta, Georgia.
Am J Trop Med Hyg. 1990 Mar;42(3):267-71. doi: 10.4269/ajtmh.1990.42.267.
An outbreak of paralytic shellfish poisoning occurred in Champerico, on the Pacific coast of Guatemala, July-August 1987. Of 187 people affected with characteristic neurologic symptoms, 26 died. A case study implicated a species of clam, Amphichaena kindermani, harvested from local beaches as the vehicle of the neurotoxins (saxitoxins). Children less than 6 years old had a higher fatality rate (50%) than people greater than 18 years of age (7%). The minimum lethal dose for 1 child was estimated to have been 140 mouse units of toxin/kg body weight; thus children may be more sensitive to the saxitoxins than are adults. This is the first large outbreak of paralytic shellfish poisoning recognized in Guatemala.
1987年7月至8月，危地马拉太平洋沿岸的钱佩里科发生了一起麻痹性贝类中毒事件。在187名出现典型神经症状的患者中，有26人死亡。一项案例研究表明，从当地海滩采集的一种蛤蜊——金德曼双带蛤，是神经毒素（石房蛤毒素）的载体。6岁以下儿童的死亡率（50%）高于18岁以上人群（7%）。据估计，一名儿童的最低致死剂量为每千克体重140个小鼠单位的毒素；因此，儿童可能比成人对石房蛤毒素更敏感。这是危地马拉首次确认的大规模麻痹性贝类中毒事件。
