水溶性衍生物 5c（DTX5c）的生物合成研究。

Biosynthetic studies on water-soluble derivative 5c (DTX5c).

机构信息

University Institute for Bio-Organic Chemistry "Antonio González", University of La Laguna, Av. Astrofísico Francisco Sánchez 2, La Laguna 38206, Spain.

Department of Organic Chemistry, Faculty of Pharmacy, University of La Laguna, Av. Astrofísico Francisco Sánchez s/n, La Laguna 38206, Spain.

出版信息

Mar Drugs. 2012 Oct;10(10):2234-2245. doi: 10.3390/md10102234. Epub 2012 Oct 12.

DOI:10.3390/md10102234

PMID:23170080

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3497019/

Abstract

The dinoflagellate Prorocentrum belizeanum is responsible for the production of several toxins involved in the red tide phenomenon known as Diarrhetic Shellfish Poisoning (DSP). In this paper we report on the biosynthetic origin of an okadaic acid water-soluble ester derivative, DTX5c, on the basis of the spectroscopical analysis of ¹³C enriched samples obtained by addition of labelled sodium [l-¹³C], [2-¹³C] acetate to artificial cultures of this dinoflagellate.

摘要

原甲藻（Prorocentrum belizeanum）是产生几种赤潮毒素的生物，这些毒素与腹泻性贝类中毒（DSP）有关。本文基于对用标记的[1-¹³C]、[2-¹³C]乙酸钠添加到该甲藻人工培养物中获得的 ¹³C 富集样品的光谱分析，报道了一种 okadaic 酸水溶性酯衍生物 DTX5c 的生物合成起源。