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通过液相色谱-质谱检测鉴定一种新型腹泻性贝类中毒毒素——19-表冈田酸。

Identification of 19-epi-okadaic acid, a new diarrhetic shellfish poisoning toxin, by liquid chromatography with mass spectrometry detection.

作者信息

Paz Beatriz, Daranas Antonio H, Cruz Patricia G, Franco José M, Norte Manuel, Fernández José J

机构信息

Fitoplancton Tóxico, Instituto de Investigaciones Marinas (CSIC), Eduardo Cabello 6, 36080 Vigo, Spain.

出版信息

Mar Drugs. 2008;6(3):489-95. doi: 10.3390/md20080024. Epub 2008 Aug 28.

DOI:10.3390/md20080024
PMID:19005581
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2579738/
Abstract

Okadaic acid (1) (OA) and its congeners are mainly responsible for diarrhetic shellfish poisoning (DSP) syndrome. The presence of several OA derivatives have already been confirmed in Prorocentrum and Dinophysis spp. In this paper, we report on the detection and identification of a new DSP toxin, the OA isomer 19-epi-okadaic acid (2) (19-epi-OA), isolated from cultures of Prorocentrum belizeanum, by determining its retention time (RT) and fragmentation pattern using liquid chromatography coupled with mass spectrometry (LC-MS/MS).

摘要

冈田酸（1）（OA）及其同系物是引发腹泻性贝类中毒（DSP）综合征的主要原因。在原甲藻属和鳍藻属物种中已证实存在多种OA衍生物。在本文中，我们报告了一种新的DSP毒素——OA异构体19-表冈田酸（2）（19-epi-OA）的检测与鉴定，该毒素是从伯利兹原甲藻培养物中分离得到的，通过液相色谱-质谱联用（LC-MS/MS）测定其保留时间（RT）和碎片模式来实现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24b3/2579738/db9c9e14bea8/md-06-00489f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24b3/2579738/f6fefebaa990/md-06-00489f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24b3/2579738/965014ec1771/md-06-00489f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24b3/2579738/db9c9e14bea8/md-06-00489f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24b3/2579738/f6fefebaa990/md-06-00489f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24b3/2579738/965014ec1771/md-06-00489f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24b3/2579738/db9c9e14bea8/md-06-00489f3.jpg

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Org Lett. 2007 Aug 2;9(16):3045-8. doi: 10.1021/ol071099i. Epub 2007 Jul 14.
2
Identification and characterization of DTX-5c and 7-hydroxymethyl-2-methylene-octa-4,7-dienyl okadaate from Prorocentrum belizeanum cultures by LC-MS.通过液相色谱-质谱联用技术从伯利兹原甲藻培养物中鉴定并表征DTX-5c和7-羟甲基-2-亚甲基-辛-4,7-二烯基冈田酸酯。
Toxicon. 2007 Sep 15;50(4):470-8. doi: 10.1016/j.toxicon.2007.04.011. Epub 2007 May 1.
3
Characterisation of okadaic acid related toxins by liquid chromatography coupled with mass spectrometry.
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Toxicon. 2007 Aug;50(2):225-35. doi: 10.1016/j.toxicon.2007.03.015. Epub 2007 Mar 28.
4
Fit-for-purpose shellfish reference materials for internal and external quality control in the analysis of phycotoxins.用于藻毒素分析中内部和外部质量控制的适用贝类参考物质。
Anal Bioanal Chem. 2007 Apr;387(7):2463-74. doi: 10.1007/s00216-006-0792-8. Epub 2006 Sep 27.
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Detailed profiles of 7-O-acyl esters in plankton and shellfish from the Portuguese coast.葡萄牙海岸浮游生物和贝类中7-O-酰基酯的详细概况。
J Chromatogr A. 2006 Sep 22;1128(1-2):181-8. doi: 10.1016/j.chroma.2006.06.072. Epub 2006 Jul 24.
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New targets in diarrhetic shellfish poisoning control.腹泻性贝类中毒控制中的新靶点。
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