孕妇阴道细菌与阴道防御素水平的相关性。
Associations between vaginal bacteria and levels of vaginal defensins in pregnant women.
机构信息
Department of Obstetrics and Gynecology, Harborview Women's Clinic, University of Washington School of Medicine, Seattle, WA, USA.
出版信息
Am J Obstet Gynecol. 2013 Feb;208(2):132.e1-7. doi: 10.1016/j.ajog.2012.11.019. Epub 2012 Nov 19.
OBJECTIVE
We evaluated vaginal defensin concentrations and levels of bacterial vaginosis-associated bacterial species in pregnant women.
STUDY DESIGN
Self-collected vaginal swabs from 2 visits during pregnancy were tested with quantitative polymerase chain reaction for 9 bacterial species. Beta defensins 2-3 and alpha defensins 1-3 were measured by enzyme-linked immunosorbent assay.
RESULTS
Our 126 participants were primarily African American (60%), had a mean gestational age at enrollment of 10 ± 3 weeks and at follow-up visit of 25 ± 6 weeks. At enrollment, the prevalence of bacterial vaginosis was 74% (94/126 women), which decreased to 60% (75/126 specimens) at follow-up visit. At enrollment, beta defensin 3 concentrations were significantly lower in women with bacterial vaginosis (2.64 ± 0.91 vs 3.25 ± 0.99 log(10) pg/mL; P = .003). Higher concentrations of Atopobium vaginae, bacterial vaginosis-associated bacteria1 and 2 were associated with significantly lower concentrations of beta defensin 3 (P < .01).
CONCLUSION
Bacterial vaginosis was associated with lower vaginal concentrations of beta defensin 3, but not beta defensin 2 or alpha defensins 1-3, in pregnant women.
目的
我们评估了孕妇阴道防御素浓度和细菌性阴道病相关细菌种类的水平。
研究设计
对妊娠期间 2 次就诊时的自我采集阴道拭子进行定量聚合酶链反应检测 9 种细菌。通过酶联免疫吸附试验检测β防御素 2-3 和α防御素 1-3。
结果
我们的 126 名参与者主要为非裔美国人（60%），在入组时的平均妊娠年龄为 10±3 周，在随访时为 25±6 周。入组时，细菌性阴道病的患病率为 74%（94/126 名女性），随访时降至 60%（75/126 标本）。入组时，细菌性阴道病患者的β防御素 3 浓度明显较低（2.64±0.91 与 3.25±0.99 log(10) pg/mL；P=0.003）。较高的 Atopobium vaginae、细菌性阴道病相关细菌 1 和 2 浓度与 β 防御素 3 的浓度显著降低相关（P<0.01）。
结论
细菌性阴道病与孕妇阴道β防御素 3 浓度降低相关，但与β防御素 2 或α防御素 1-3 无关。
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