TNF-α -308 G/A、IL6 -174 G/C 和 AdipoQ 45 T/G 多态性与巴西人心血管代谢高危人群生活方式干预的炎症和代谢反应的关联。
Associations of the TNF-alpha -308 G/A, IL6 -174 G/C and AdipoQ 45 T/G polymorphisms with inflammatory and metabolic responses to lifestyle intervention in Brazilians at high cardiometabolic risk.
机构信息
Department of Nutrition, School of Public Health, University of Sao Paulo, Av, Dr, Arnaldo, São Paulo, SP, 715, Brasil.
出版信息
Diabetol Metab Syndr. 2012 Nov 24;4(1):49. doi: 10.1186/1758-5996-4-49.
BACKGROUND
Cytokines secreted by the adipose tissue influence inflammation and insulin sensitivity, and lead to metabolic disturbances. How certain single-nucleotide polymorphisms (SNPs) interfere on lifestyle interventions is unclear. We assessed associations of selected SNPs with changes induced by a lifestyle intervention.
METHODS
This 9-month intervention on diet and physical activity included 180 Brazilians at high cardiometabolic risk, genotyped for the TNF-α -308 G/A, IL-6 -174 G/C and AdipoQ 45 T/G SNPs. Changes in metabolic and inflammatory variables were analyzed according to these SNPs. Individuals with at least one variant allele were grouped and compared with those with the reference genotype.
RESULTS
In the entire sample (66.7% women; mean age 56.5 ± 11.6 years), intervention resulted in lower energy intake, higher physical activity, and improvement in anthropometry, plasma glucose, HOMA-IR, lipid profile and inflammatory markers, except for IL-6 concentrations. After intervention, only variant allele carriers of the TNF-α -308 G/A decreased plasma glucose, after adjusting for age and gender (OR 2.96, p = 0.025). Regarding the IL6 -174 G/C SNP, carriers of the variant allele had a better response of lipid profile and adiponectin concentration, but only the reference genotype group decreased plasma glucose. In contrast to individuals with the reference genotype, carriers of variant allele of AdipoQ 45 T/G SNP did not change plasma glucose, apolipoprotein B, HDL-c and adiponectin concentrations in response to intervention.
CONCLUSION
The TNFα -308 G/A SNP may predispose a better response of glucose metabolism to lifestyle intervention. The IL-6 -174 G/C SNP may confer a beneficial effect on lipid but not on glucose metabolism. Our findings reinforce unfavorable effects of the AdipoQ 45 T/G SNP in lipid profile and glucose metabolism after intervention in Brazilians at cardiometabolic risk. Further studies are needed to direct lifestyle intervention to subsets of individuals at cardiometabolic risk.
背景
脂肪组织分泌的细胞因子影响炎症和胰岛素敏感性，并导致代谢紊乱。某些单核苷酸多态性（SNP）如何干扰生活方式干预尚不清楚。我们评估了选定的 SNP 与生活方式干预诱导的变化之间的关联。
方法
这项为期 9 个月的饮食和体育活动干预措施包括 180 名处于高心血管代谢风险的巴西人，对 TNF-α-308G/A、IL-6-174G/C 和 AdipoQ45T/G SNP 进行了基因分型。根据这些 SNP 分析了代谢和炎症变量的变化。将至少携带一个变异等位基因的个体分为一组，并与具有参考基因型的个体进行比较。
结果
在整个样本中（66.7%为女性；平均年龄 56.5±11.6 岁），干预措施导致能量摄入减少、体力活动增加，以及人体测量、血浆葡萄糖、HOMA-IR、血脂谱和炎症标志物的改善，除了 IL-6 浓度。干预后，只有 TNF-α-308G/A SNP 的变异等位基因携带者在调整年龄和性别后，血浆葡萄糖降低（OR2.96，p=0.025）。关于 IL6-174G/C SNP，变异等位基因携带者的血脂谱和脂联素浓度反应更好，但只有参考基因型组的血浆葡萄糖降低。与具有参考基因型的个体相比，AdipoQ45T/G SNP 的变异等位基因携带者在干预后不会改变血浆葡萄糖、载脂蛋白 B、HDL-c 和脂联素浓度。
结论
TNFα-308G/A SNP 可能使葡萄糖代谢对生活方式干预的反应更好。IL-6-174G/C SNP 可能对脂质代谢有益，但对葡萄糖代谢无益。我们的研究结果加强了 AdipoQ45T/G SNP 在心血管代谢风险的巴西人干预后对血脂谱和葡萄糖代谢的不利影响。需要进一步的研究来指导心血管代谢风险个体的生活方式干预。
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