McClinton S, Moffat L E, Scott S, Urbaniak S J, Kerridge D F
Department of Urology, Royal Infirmary, Aberdeen, UK.
Br J Surg. 1990 Feb;77(2):140-2. doi: 10.1002/bjs.1800770208.
Blood transfusion in the perioperative period has been reported to have a detrimental effect on survival in many types of cancer. Other studies have failed to confirm this. We have examined retrospectively the records of 246 patients with prostatic carcinoma who underwent transurethral resection of the prostate (TURP) in Aberdeen Royal Infirmary between 1977 and 1982. Bilateral orchiectomy (BLO) was performed in 193 patients. Of these patients, 71 of 246 (29 per cent) received perioperative blood transfusion. After controlling for differences due to a number of variables, transfusion of non-autologous blood was shown to be associated with a significant negative effect on survival. Perioperative transfusion of non-autologous blood should be avoided in patients with malignancy, unless there are clear overriding clinical indications. Prospective trials are needed urgently.
据报道，围手术期输血对多种癌症患者的生存率有不利影响。其他研究未能证实这一点。我们回顾性研究了1977年至1982年间在阿伯丁皇家医院接受经尿道前列腺切除术（TURP）的246例前列腺癌患者的记录。193例患者接受了双侧睾丸切除术（BLO）。在这些患者中，246例中有71例（29%）接受了围手术期输血。在控制了多个变量造成的差异后，非自体血输血被证明对生存率有显著负面影响。除非有明确压倒一切的临床指征，否则恶性肿瘤患者应避免围手术期非自体血输血。迫切需要进行前瞻性试验。
