Buhr J, Berghäuser K H, Morr H, Dobroschke J, Ebner H J
Medical Center of Pathology, Justus Liebig University, Giessen, FRG.
Cancer. 1990 Apr 15;65(8):1801-4. doi: 10.1002/1097-0142(19900415)65:8<1801::aid-cncr2820650822>3.0.co;2-9.
Fifty-nine patients with bronchogenic carcinoma and 21 patients with nonneoplastic lung diseases underwent intraoperative pleural lavage with 300-ml physiologic saline before (Lavage I) and after resection (Lavage II). The presence of tumor cells in the lavage fluid was established cytologically in 29 patients with bronchogenic carcinoma. Twenty-seven had positive findings in Lavage I and 23 of these also in Lavage II. Two patients had positive findings in Lavage II only. All controls were negative. In all 40% of patients with Stage I bronchogenic carcinoma had positive lavage results. The cumulative two-year survival rate of this group is 40%, which differs significantly (P less than 0.01) from the 97% survival rate of the patients with the same tumor stage whose lavage findings were negative. Detection of tumor cells in pleural cavity washings before resection proves that tumor cells have spread into the pleural cavity. Cytologic examination of an intraoperative pleural lavage should be done when assessing the tumor stage.
59例支气管源性癌患者和21例非肿瘤性肺部疾病患者在切除术前（灌洗I）和切除术后（灌洗II）接受了300毫升生理盐水的术中胸腔灌洗。通过细胞学检查确定29例支气管源性癌患者的灌洗液中存在肿瘤细胞。27例在灌洗I中有阳性发现，其中23例在灌洗II中也呈阳性。2例仅在灌洗II中有阳性发现。所有对照均为阴性。所有I期支气管源性癌患者中40%的灌洗结果为阳性。该组的累积两年生存率为40%，与灌洗结果为阴性的相同肿瘤分期患者的97%生存率相比有显著差异（P<0.01）。切除术前在胸腔冲洗液中检测到肿瘤细胞证明肿瘤细胞已扩散至胸腔。在评估肿瘤分期时应进行术中胸腔灌洗的细胞学检查。
