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用于细胞病理学评估的积液采集与处理

Collection and processing of effusion fluids for cytopathologic evaluation.

作者信息

Shidham Vinod B

机构信息

Department of Pathology, Wayne State University School of Medicine, Karmanos Cancer Center, and Detroit Medical Center, Detroit, Michigan, USA.

出版信息

Cytojournal. 2022 Jan 31;19:5. doi: 10.25259/CMAS_02_14_2021. eCollection 2022.

DOI:10.25259/CMAS_02_14_2021
PMID:35541031
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9079316/
Abstract

Accumulation of fluid in serous cavities as effusions may have to be drained for therapeutic and diagnostic indications. As compared to many other procedures, the technicality of paracentesis procedures is relatively easy. As a result, effusion fluids comprise a significant proportion of specimens in most of the laboratories, including those in community settings. Because of relative complexities in the cytopathologic evaluation of effusion fluids, application of appropriately standardized protocol is critical for achieving optimum results by applying standardized steps from handling of specimens during the initial stages of collection to the final interpretation phase. Understanding various limitations and challenges during collection and processing phases by all the personnel involved, including clinicians, pathologists, and technologists is critical for optimum diagnostic yield. This review highlights various cytopreparatory techniques applicable to effusion cytology in one place. It is organized by projecting the details predominantly in the form of different tables and figures including summary of the recommended protocols with reagents and stains used. Also included is a sample of cytopathology report based on the approach discussed in this series.

摘要

作为积液的浆液腔中的液体蓄积可能因治疗和诊断指征而需要引流。与许多其他操作相比，穿刺术的技术相对简单。因此，在大多数实验室，包括社区环境中的实验室，积液样本占标本的很大比例。由于积液的细胞病理学评估相对复杂，应用适当标准化的方案对于通过应用从标本采集初始阶段的处理到最终解释阶段的标准化步骤来获得最佳结果至关重要。包括临床医生、病理学家和技术人员在内的所有相关人员了解采集和处理阶段的各种局限性和挑战对于获得最佳诊断率至关重要。本综述集中介绍了适用于积液细胞学的各种细胞制备技术。它主要以不同表格和图表的形式呈现细节，包括推荐方案的总结以及所使用的试剂和染色剂。还包括基于本系列讨论方法的细胞病理学报告样本。

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