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CircaDB:哺乳动物生物钟基因表达谱数据库。

CircaDB: a database of mammalian circadian gene expression profiles.

机构信息

The Institute for Translational Medicine and Therapeutics, University of Pennsylvania, 3400 Civic Center Boulevard, Building 421, Philadelphia, PA 19104, USA.

出版信息

Nucleic Acids Res. 2013 Jan;41(Database issue):D1009-13. doi: 10.1093/nar/gks1161. Epub 2012 Nov 24.

Abstract

CircaDB (http://circadb.org) is a new database of circadian transcriptional profiles from time course expression experiments from mice and humans. Each transcript's expression was evaluated by three separate algorithms, JTK_Cycle, Lomb Scargle and DeLichtenberg. Users can query the gene annotations using simple and powerful full text search terms, restrict results to specific data sets and provide probability thresholds for each algorithm. Visualizations of the data are intuitive charts that convey profile information more effectively than a table of probabilities. The CircaDB web application is open source and available at http://github.com/itmat/circadb.

摘要

CircaDB(http://circadb.org)是一个新的数据库,包含来自小鼠和人类时间进程表达实验的昼夜转录谱。每个转录本的表达都通过三种独立的算法进行评估,即 JTK_Cycle、 Lomb Scargle 和 DeLichtenberg。用户可以使用简单而强大的全文搜索词查询基因注释,将结果限制在特定的数据集,并为每个算法提供概率阈值。数据的可视化是直观的图表,比概率表更有效地传达了谱信息。CircaDB 网络应用程序是开源的,可在 http://github.com/itmat/circadb 获得。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c39f/3531170/fe2b4fcf3402/gks1161f1p.jpg

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