Turton C W, Grundy E, Firth G, Mitchell D, Rigden B G, Turner-Warwick M
Thorax. 1979 Feb;34(1):57-62. doi: 10.1136/thx.34.1.57.
Serum angiotensin I converting enzyme (ACE) and lysozyme have been measured in 23 controls, 115 patients with sarcoidosis, and 64 with other chest diseases. Both enzymes were significantly raised in sarcoidosis. ACE was raised above the normal range in 21 of 72 (29%) patients with definite sarcoidosis and in 17 of 38 (45%) of those who were untreated and seen within one year of presentation. The rise discriminated usefully between those with stable and progressive disease (5% and 62% respectively). Lysozyme was raised in 50 of 72 (69%) patients with sarcoidosis but also in 11 of 54 (20%) patients with other chest diseases. Discrimination between stable and progressive disease was useful only if very high levels were considered. Five patients had serial measurements after treatment with oral steroids and showed a progressive fall in levals of both enzymes, but patients with other diseases also showed a significant fall within the normal range when so treated. Measurement of these enzymes may help in the management of some cases of sarcoidosis, but results require critical interpretation.
对23名对照者、115名结节病患者和64名患有其他胸部疾病的患者进行了血清血管紧张素I转换酶（ACE）和溶菌酶的检测。在结节病患者中，这两种酶的水平均显著升高。在72名确诊结节病的患者中，有21名（29%）的ACE水平高于正常范围；在38名未接受治疗且在发病后一年内就诊的患者中，有17名（45%）的ACE水平高于正常范围。这种升高有助于区分病情稳定和病情进展的患者（分别为5%和62%）。72名结节病患者中有50名（69%）的溶菌酶水平升高，但54名患有其他胸部疾病的患者中也有11名（20%）的溶菌酶水平升高。只有在考虑非常高的水平时，溶菌酶水平才有助于区分病情稳定和病情进展的患者。5名患者在接受口服类固醇治疗后进行了系列检测，结果显示两种酶的水平均逐渐下降，但其他疾病患者在接受同样治疗后，其酶水平在正常范围内也有显著下降。检测这些酶可能有助于某些结节病病例的管理，但结果需要审慎解读。
