Ma Charles, Gunther Svenja, Cooke Brian, Coppel Ross L
Department of Microbiology, Monash University, Clayton Vic 3800, Australia.
Parasitol Int. 2013 Apr;62(2):134-6. doi: 10.1016/j.parint.2012.11.003. Epub 2012 Nov 24.
The bioinformatics software, Geneious, provides a useful platform for researchers to retrieve and analyse genomic and functional genomics information. However, the main databases that the software is able to access are hosted by NCBI (National Center for Biotechnology Information). The databases of EuPathDB (Eukaryotic Pathogen Database Resources), such as PlasmoDB and PiroplasmaDB, collect more specific and detailed information about eukaryotic pathogens than those kept in NCBI databases. Two plugins for Geneious, one for PlasmaDB and one for PiroplasmaDB were developed. When installed, users can use search facilities to find and import gene and protein sequences from the EuPathDB databases. Users can then use the functions of Geneious to process the sequence information. When information unique to PlasmoDB and PiroplasmaDB is required, the user can access results linked with the gene/protein sequence via the default web browser. The plugins are freely available from the Victorian Bioinformatics Consortium website. The plugins can be modified to access any of the databases of EuPathDB.
生物信息学软件Geneious为研究人员检索和分析基因组及功能基因组学信息提供了一个有用的平台。然而,该软件能够访问的主要数据库由美国国家生物技术信息中心(NCBI)托管。真核病原体数据库资源(EuPathDB)的数据库,如疟原虫数据库(PlasmoDB)和梨形虫数据库(PiroplasmaDB),收集的关于真核病原体的信息比NCBI数据库中的信息更具体、更详细。开发了两个用于Geneious的插件,一个用于PlasmoDB,一个用于PiroplasmaDB。安装后,用户可以使用搜索工具从EuPathDB数据库中查找并导入基因和蛋白质序列。然后,用户可以使用Geneious的功能来处理序列信息。当需要PlasmoDB和PiroplasmaDB特有的信息时,用户可以通过默认的网络浏览器访问与基因/蛋白质序列相关的结果。这些插件可从维多利亚生物信息学联盟网站免费获取。这些插件可以进行修改,以访问EuPathDB的任何数据库。