Faculdade de Medicina da Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Departamento de Medicina Interna, Porto Alegre/RS, Brazil.
Clinics (Sao Paulo). 2012 Nov;67(11):1321-5. doi: 10.6061/clinics/2012(11)17.
Community-acquired pneumonia (CAP) exhibits mortality rates, between 20% and 50% in severe cases. Biomarkers are useful tools for searching for antibiotic therapy modifications and for CAP diagnosis, prognosis and follow-up treatment. This non-systematic state-of-the-art review presents the biological and clinical features of biomarkers in CAP patients, including procalcitonin, C-reactive protein, copeptin, pro-ANP (atrial natriuretic peptide), adrenomedullin, cortisol and D-dimers.
社区获得性肺炎(CAP)在重症病例中的死亡率在 20%至 50%之间。生物标志物是寻找抗生素治疗改变以及 CAP 诊断、预后和随访治疗的有用工具。本文对生物标志物在 CAP 患者中的生物学和临床特征进行了非系统性的综述,包括降钙素原、C 反应蛋白、 copeptin、pro-ANP(心房利钠肽)、肾上腺髓质素、皮质醇和 D-二聚体。