Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Adv Healthc Mater. 2012 Sep;1(5):567-72. doi: 10.1002/adhm.201200116. Epub 2012 Jun 8.
Spatiotemporal control over the delivery of therapeutic agents is an outstanding challenge to cancer treatment. By taking advantage of recent advances in DNA aptamer biology and mesoporous silica nanotechnology, we report a general approach to design and fabricate controlled release drug delivery systems that are able to effectively target cancer cells. Specifically, polyvalent mesoporous silica nanocarriers-aptamer bioconjugates were constructed; the high-surface-area nanoporous core allowed high drug loading and the surface-conjugated aptamer facilitated the nanoparticle targeting of nucleolin overexpressed MCF-7 cells. The efficient cancer-cell-specific fluorescent imaging and drug delivery of the bioconjugates outline the great potential for therapeutic applications.
时空控制治疗剂的递送是癌症治疗的一个突出挑战。利用 DNA 适体生物学和介孔硅纳米技术的最新进展，我们报告了一种设计和制造能够有效靶向癌细胞的控制释放药物递送系统的通用方法。具体来说，构建了多价介孔硅纳米载体-适体生物缀合物；高表面积的纳米多孔核允许高药物负载，表面共轭的适体促进了核仁素过表达 MCF-7 细胞的纳米颗粒靶向。生物缀合物的高效癌细胞特异性荧光成像和药物递送概述了其在治疗应用中的巨大潜力。
