Choi Hyunmin, Park Nho-Jae, Jamiyandorj Otgonbold, Hong Min-Ho, Oh Seunghan, Park Young-Bum, Kim Sungtae
Department of Prosthodontics, Yonsei University College of Dentistry, Seoul, Korea.
J Periodontal Implant Sci. 2012 Oct;42(5):166-72. doi: 10.5051/jpis.2012.42.5.166. Epub 2012 Oct 31.
The aim of this study was to evaluate the improvement of osteogenic potential of biphasic calcium phosphate (BCP) bone substitute coated with synthetic cell-binding peptide sequences in a standardized rabbit sinus model.
Standardized 6-mm diameter defects were created bilaterally on the maxillary sinus of ten male New Zealand white rabbits, receiving BCP bone substitute coated with synthetic cell binding peptide sequences on one side (experimental group) and BCP bone substitute without coating (control group) on the other side. Histologic and histomorphometric analysis of bone formation was carried out after a healing period of 4 or 8 weeks.
Histological analysis revealed signs of new bone formation in both experimental groups (4- and 8-week healing groups) with a statistically significant increase in bone formation in the 4-week healing group compared to the control group. However, no statistically significant difference in bone formation was found between the 8-week healing group and the control group.
This study found that BCP bone substitute coated with synthetic cell-binding peptide sequences enhanced osteoinductive potential in a standardized rabbit sinus model and its effectiveness was greater in the 4-week healing group than in the 8-week healing group.
本研究旨在评估在标准化兔鼻窦模型中，涂覆合成细胞结合肽序列的双相磷酸钙（BCP）骨替代物的成骨潜力改善情况。
在十只雄性新西兰白兔的双侧上颌窦上制造直径6毫米的标准化缺损，一侧植入涂覆合成细胞结合肽序列的BCP骨替代物（实验组），另一侧植入未涂覆的BCP骨替代物（对照组）。在4周或8周的愈合期后，对骨形成进行组织学和组织形态计量学分析。
组织学分析显示，两个实验组（4周和8周愈合组）均有新骨形成迹象，4周愈合组的骨形成与对照组相比有统计学意义的增加。然而，8周愈合组与对照组之间在骨形成方面未发现统计学显著差异。
本研究发现，涂覆合成细胞结合肽序列的BCP骨替代物在标准化兔鼻窦模型中增强了骨诱导潜力，且其在4周愈合组中的有效性高于8周愈合组。
