Bakker D, van Blitterswijk C A, Hesseling S C, Daems W T, Grote J J
Ear, Nose & Throat Department, University Hospital, Leiden, The Netherlands.
J Biomed Mater Res. 1990 Mar;24(3):277-93. doi: 10.1002/jbm.820240302.
The tissue/biomaterial interface reactions of four elastomers--selected as candidates for scaffolding for tympanic membrane tissue in a total alloplastic middle ear prosthesis--were studied at the electron microscopical level after implantation in the rat middle ear. Time-dependent changes in the phagocyte/polymer interface suggested degradation of porous implants made of Estane polyether urethane, polypropylene oxide, and a poly(ethylene oxide hydantoin) and poly(tetramethylene terephthalate) segmented polyether polyester copolymer (HPOE/PBT copolymer), but not of dense Silastic silicone rubber implants. Silastic was always encapsulated in fibrous tissue. Contact between fibrous tissue and HPOE/PBT copolymer or Estane was established in the third month, but fibrous tissue was never seen close to polypropylene oxide. Bone made contact only with Estane and HPOE/PBT copolymer implants. The bone/copolymer interface showed an electron-dense layer morphologically similar to that seen between bone and hydroxyapatite ceramic, suggesting that with respect to bone HPOE/PBT copolymer behaves like a bioactive implant material. The electron-dense layer was absnet at the bone/Estane interface. Estane and especially HPOE/PBT copolymer seem to be suitable as alloplastic tympanic membrane because of their interface behavior with respect to fibrous tissue and bone.
在大鼠中耳植入后，对四种弹性体（选为全塑料中耳假体中鼓膜组织支架的候选材料）的组织/生物材料界面反应进行了电子显微镜水平的研究。吞噬细胞/聚合物界面的时间依赖性变化表明，由依斯塔醚聚氨酯、聚环氧丙烷、聚（乙内酰脲环氧乙烷）和聚对苯二甲酸丁二醇酯嵌段聚醚聚酯共聚物（HPOE/PBT共聚物）制成的多孔植入物会降解，但致密的硅橡胶植入物不会降解。硅橡胶总是被纤维组织包裹。在第三个月时，纤维组织与HPOE/PBT共聚物或依斯塔醚之间建立了接触，但从未在聚环氧丙烷附近看到纤维组织。骨仅与依斯塔醚和HPOE/PBT共聚物植入物接触。骨/共聚物界面显示出一个电子致密层，其形态与骨和羟基磷灰石陶瓷之间的相似，这表明就骨而言，HPOE/PBT共聚物表现得像一种生物活性植入材料。骨/依斯塔醚界面没有电子致密层。由于依斯塔醚尤其是HPOE/PBT共聚物在与纤维组织和骨的界面行为方面的表现，它们似乎适合作为全塑料鼓膜。
