Bakker D, van Blitterswijk C A, Hesseling S C, Grote J J
Ear, Nose and Throat Department, University of Leiden, The Netherlands.
Biomaterials. 1988 Jan;9(1):14-23. doi: 10.1016/0142-9612(88)90064-6.
Implants of Silastic, Estane, polypropylene oxide and an HPOE/PBT segmented polyether polyester copolymer were qualitatively and quantitatively evaluated, with respect to interaction with mononuclear and multinucleated phagocytes as well as fibrous capsule formation, after implantation at three sites in the rat middle ear. The volume of the phagocyte exudate surrounding the implants, the degree of implant degradation and fragmentation and the thickness of the fibrous capsules were found to be correlated with the implantation site. From these findings, it can be concluded that it is important to assess the biological performance of a biomaterial at carefully chosen implantation sites.
对硅橡胶、依斯特兰、聚环氧丙烷和一种HPOE/PBT嵌段聚醚聚酯共聚物植入物进行了定性和定量评估，观察其在大鼠中耳三个部位植入后与单核和多核吞噬细胞的相互作用以及纤维囊形成情况。发现植入物周围吞噬细胞渗出物的体积、植入物降解和破碎程度以及纤维囊的厚度与植入部位相关。从这些发现可以得出结论，在精心选择的植入部位评估生物材料的生物学性能很重要。
