Chowhan Amit K, Rukmangadha Nandyala, Patnayak Rashmi, Bodapati Chandra Mouliswara Prasad, Bodagala Vijaya Laxmi, Reddy Mandyam Kumaraswamy
Department of Pathology, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India.
J Neurosci Rural Pract. 2012 Sep;3(3):395-8. doi: 10.4103/0976-3147.102641.
The myxoid variant of chondrosarcoma is usually seen in soft tissues where it is known as chordoid sarcoma or parachordoma. Rarely, it involves bone and when it does, cranial bones are the preferred location. This tumor is frequently amalgamated with the chondroid variant of chordoma, especially when the lesion occurs in the sphenoid bone/spheno-occipital region, because of their similar clinical presentations, anatomical locations, radiological findings, and mistaken histopathological features. It is essential to distinguish myxoid chondrosarcoma from the chondroid variant of chordoma, because of the different treatment protocol and prognostic importance. We present such a location-based diagnostic dilemma, solved successfully with ancillary immunohistochemistry.
软骨肉瘤的黏液样变体通常见于软组织，在软组织中它被称为脊索样肉瘤或副脊索瘤。很少情况下，它会累及骨骼，若累及骨骼，颅骨是最常受累的部位。这种肿瘤常与脊索瘤的软骨样变体合并，尤其是当病变发生在蝶骨/蝶枕区域时，因为它们具有相似的临床表现、解剖位置、影像学表现和容易混淆的组织病理学特征。由于治疗方案和预后意义不同，区分黏液样软骨肉瘤和脊索瘤的软骨样变体至关重要。我们展示了这样一个基于部位的诊断难题，并通过辅助免疫组化成功解决。
