Natural and Microbial Department, National Research Centre, Dokki, Cairo 12311, Egypt.
Mini Rev Med Chem. 2013 Mar;13(3):399-407. doi: 10.2174/138955713804999847.
Benzimidazole ring system is found in many bioactive heterocyclic compounds because of their diverse biological and clinical applications. Furthermore, benzimidazole derivatives are structural isosters of naturally occurring nucleotides, thus they can interact with biological macromolecules such as proteins, enzymes and receptors. This review discusses the benzimidazole derivatives which possess anticancer activity of medicinal efficacy.
苯并咪唑环系统存在于许多具有生物活性的杂环化合物中，因为它们具有多种多样的生物和临床应用。此外，苯并咪唑衍生物是天然存在的核苷酸的结构类似物，因此它们可以与生物大分子如蛋白质、酶和受体相互作用。本综述讨论了具有药用疗效的抗癌活性的苯并咪唑衍生物。
