Laboratorio de Organocatálisis Asimétrica, Departamento de Química Orgánica. Instituto de Síntesis Química y Catálisis Homogénea (ISQCH), CSIC-Universidad de Zaragoza. C/Pedro Cerbuna 12, E-50009 Zaragoza, Spain.
Curr Med Chem. 2023;30(10):1145-1174. doi: 10.2174/0929867329666220829091830.
Among the aromatic heterocycle rings, pyrazole -a five-membered ring with two adjacent nitrogen atoms in its structure has been postulated as a potent candidate in the pharmacological context. This moiety is an interesting therapeutic target covering a broad spectrum of biological activities due to its presence in many natural substances. Hence, the potential of the pyrazole derivatives as antitumor agents has been explored in many investigations, showing promising results in some cases. In this sense, breast cancer, which is already the leading cause of cancer mortality in women in some countries, has been the topic selected for this review, which covers a range of different research from the earliest studies published in 2003 to the most recent ones in 2021.
在芳香杂环环中，吡唑 - 结构中具有两个相邻氮原子的五元环，已被假定为药理学背景下的有力候选物。由于其存在于许多天然物质中，该部分是一个有趣的治疗靶标，涵盖了广泛的生物活性。因此，吡唑衍生物作为抗肿瘤剂的潜力已在许多研究中得到探索，在某些情况下显示出有希望的结果。在这个意义上，乳腺癌，在某些国家已经是女性癌症死亡率的主要原因，已经成为本综述的主题，涵盖了从 2003 年发表的最早研究到 2021 年的最新研究的一系列不同的研究。
