Taitt Chris Rowe, Anderson George P, Ligler Frances S
Center for Bio/Molecular Science and Engineering, US Naval Research Laboratory, 4555 Overlook Ave SW, Washington, DC 20375-5348, USA.
UNC-Chapel Hill and NC State University Department of Biomedical Engineering, 911 Oval Drive, Raleigh, NC 27695-7115, USA.
Biosens Bioelectron. 2016 Feb 15;76:103-12. doi: 10.1016/j.bios.2015.07.040. Epub 2015 Jul 20.
Biosensor development has been a highly dynamic field of research and has progressed rapidly over the past two decades. The advances have accompanied the breakthroughs in molecular biology, nanomaterial sciences, and most importantly computers and electronics. The subfield of evanescent wave fluorescence biosensors has also matured dramatically during this time. Fundamentally, this review builds on our earlier 2005 review. While a brief mention of seminal early work will be included, this current review will focus on new technological developments as well as technology commercialized in just the last decade. Evanescent wave biosensors have found a wide array applications ranging from clinical diagnostics to biodefense to food testing; advances in those applications and more are described herein.
生物传感器的发展一直是一个充满活力的研究领域，在过去二十年中取得了迅速进展。这些进展伴随着分子生物学、纳米材料科学，以及最重要的计算机和电子学领域的突破。在此期间，倏逝波荧光生物传感器子领域也取得了显著成熟。从根本上说，本综述建立在我们2005年的早期综述基础之上。虽然将简要提及早期的开创性工作，但本综述将重点关注新技术发展以及仅在过去十年中实现商业化的技术。倏逝波生物传感器已在从临床诊断到生物防御再到食品检测等广泛领域得到应用；本文将介绍这些应用及更多方面的进展。
