Hochberg F, Toniolo P, Cole P, Salcman M
Department of Neurology, Massachusetts General Hospital, Boston, MA 02114.
J Neurooncol. 1990 Feb;8(1):55-60. doi: 10.1007/BF00182087.
A case-control study of brain tumor was conducted in collaborating hospitals in Boston, Providence, and Baltimore. Cases were 160 consecutive patients being treated for glioblastoma, grade 3 or 4 astrocytoma, or anaplastic astrocytoma. Controls were 128 healthy persons identified among the case's friends. A complex self-administered questionnaire was used to assess exposure to factors of interest. There was some evidence that glioblastoma is associated with a decreased susceptibility to allergies, a finding that may call attention to the involvement of immunologic disturbances in brain tumors. Our data are not supportive of previous reports of an association between brain tumors and exposure to pets or farm environment, family history of CNS malignancies or other neurologic conditions, or irradiation to the head. We did not find any evidence for an association with life-style characteristics such as cigarette smoking, alcohol consumption, use of drugs of any kind, or dietary intake of cured or smoked meat or fish.
在波士顿、普罗维登斯和巴尔的摩的合作医院开展了一项脑肿瘤病例对照研究。病例为160例连续接受治疗的胶质母细胞瘤、3级或4级星形细胞瘤或间变性星形细胞瘤患者。对照是在病例的朋友中确定的128名健康人。使用一份复杂的自填问卷来评估对感兴趣因素的暴露情况。有一些证据表明胶质母细胞瘤与过敏易感性降低有关，这一发现可能会引起对免疫紊乱在脑肿瘤中所起作用的关注。我们的数据不支持先前关于脑肿瘤与接触宠物或农场环境、中枢神经系统恶性肿瘤或其他神经系统疾病的家族史、或头部照射之间存在关联的报告。我们没有发现与吸烟、饮酒、使用任何种类的药物、或食用腌制或烟熏肉类或鱼类的饮食摄入等生活方式特征有关联的任何证据。
